[HTML][HTML] mRNA-based therapeutics: powerful and versatile tools to combat diseases

S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

[HTML][HTML] NAFLD: mechanisms, treatments, and biomarkers

F Nassir - Biomolecules, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

[HTML][HTML] Emerging role of non‐coding RNA in health and disease

GK Bhatti, N Khullar, IS Sidhu, US Navik… - Metabolic brain …, 2021 - Springer
Human diseases have always been a significant turf of concern since the origin of mankind.
It is cardinal to know the cause, treatment, and cure for every disease condition. With the …

The progress and promise of RNA medicine─ an arsenal of targeted treatments

JM Sasso, BJB Ambrose, R Tenchov… - Journal of Medicinal …, 2022 - ACS Publications
In the past decade, there has been a shift in research, clinical development, and commercial
activity to exploit the many physiological roles of RNA for use in medicine. With the rapid …

[HTML][HTML] Causes of and molecular targets for the treatment of intervertebral disc degeneration: a review

T Ohnishi, N Iwasaki, H Sudo - Cells, 2022 - mdpi.com
Intervertebral disc degeneration (IVDD) is a pathological condition that can lead to
intractable back pain or secondary neurological deficits. There is no fundamental cure for …

[HTML][HTML] The role of microRNAs in neurodegenerative diseases: A review

S Li, Z Lei, T Sun - Cell Biology and Toxicology, 2023 - Springer
MicroRNAs (miRNAs) are non-coding RNAs which are essential post-transcriptional gene
regulators in various neuronal degenerative diseases and playact a key role in these …

A novel identified circular RNA, mmu_mmu_circRNA_0000309, involves in germacrone-mediated improvement of diabetic nephropathy through regulating ferroptosis …

J Jin, Y Wang, D Zheng, M Liang… - Antioxidants & Redox …, 2022 - liebertpub.com
Aims: Diabetic nephropathy (DN) is characterized by microalbuminuria, mainly associated
with pathological and morphological alterations of podocyte. New drug targeting podocyte …

[HTML][HTML] Artificial intelligence, healthcare, clinical genomics, and pharmacogenomics approaches in precision medicine

H Abdelhalim, A Berber, M Lodi, R Jain, A Nair… - Frontiers in …, 2022 - frontiersin.org
Precision medicine has greatly aided in improving health outcomes using earlier diagnosis
and better prognosis for chronic diseases. It makes use of clinical data associated with the …

[HTML][HTML] Oxygen toxicity: cellular mechanisms in normobaric hyperoxia

R Alva, M Mirza, A Baiton, L Lazuran… - Cell Biology and …, 2023 - Springer
In clinical settings, oxygen therapy is administered to preterm neonates and to adults with
acute and chronic conditions such as COVID-19, pulmonary fibrosis, sepsis, cardiac arrest …

[HTML][HTML] CircPVT1: a pivotal circular node intersecting Long Non-Coding-PVT1 and c-MYC oncogenic signals

AC Palcau, V Canu, S Donzelli, S Strano, C Pulito… - Molecular Cancer, 2022 - Springer
The role of circular RNAs in oncogenesis has begun to be widely studied in recent years,
due to the significant impact that these molecules have in disease pathogenesis, as well as …