[PDF][PDF] Cardiac amyloidosis: an update on diagnosis and treatment

JP Donnelly, M Hanna - Cleve Clin J Med, 2017 - cdn.mdedge.com
Cardiac amyloidosis (CA), once thought to be a rare disease, is increasingly recognized due
to enhanced clinical awareness and better diagnostic imaging. CA is becoming of …

CCS/CHFS heart failure guidelines: clinical trial update on functional mitral regurgitation, SGLT2 inhibitors, ARNI in HFpEF, and tafamidis in amyloidosis

E O'meara, M McDonald, M Chan, A Ducharme… - Canadian Journal of …, 2020 - Elsevier
In this update, we focus on selected topics of high clinical relevance for health care
providers who treat patients with heart failure (HF), on the basis of clinical trials published …

Evolving landscape in the management of transthyretin amyloidosis

PN Hawkins, Y Ando, A Dispenzeri… - Annals of …, 2015 - Taylor & Francis
Transthyretin (TTR) amyloidosis (ATTR amyloidosis) is a multisystemic, multigenotypic
disease resulting from deposition of insoluble ATTR amyloid fibrils in various organs and …

Cardiac amyloidosis: overlooked, underappreciated, and treatable

J Rubin, MS Maurer - Annual Review of Medicine, 2020 - annualreviews.org
Cardiac amyloidosis (CA) is an infiltrative and restrictive cardiomyopathy that leads to heart
failure, reduced quality of life, and death. The disease has two main subtypes, transthyretin …

Diagnostic imaging of cardiac amyloidosis

A Martinez-Naharro, AJ Baksi, PN Hawkins… - Nature Reviews …, 2020 - nature.com
Systemic amyloidosis encompasses a debilitating, under-diagnosed but increasingly
recognized group of disorders characterized by the extracellular deposition of misfolded …

Imaging cardiac amyloidosis: a pilot study using 18F-florbetapir positron emission tomography

S Dorbala, D Vangala, J Semer, C Strader… - European journal of …, 2014 - Springer
Purpose Cardiac amyloidosis, a restrictive heart disease with high mortality and morbidity, is
underdiagnosed due to limited targeted diagnostic imaging. The primary aim of this study …

Light-chain cardiac amyloidosis: strategies to promote early diagnosis and cardiac response

M Grogan, A Dispenzieri, MA Gertz - Heart, 2017 - heart.bmj.com
Amyloid light chain (AL) amyloidosis is a systemic disease characterised by the aggregation
of misfolded immunoglobulin light chain (LC), predominantly in the heart and kidneys …

Natural history and therapy of TTR-cardiac amyloidosis: emerging disease-modifying therapies from organ transplantation to stabilizer and silencer drugs

A Castaño, BM Drachman, D Judge, MS Maurer - Heart failure reviews, 2015 - Springer
Transthyretin-cardiac amyloidoses (ATTR-CA) are an underdiagnosed but increasingly
recognized cause of heart failure. Extracellular deposition of fibrillary proteins into tissues …

JCS/JHFS 2018 guideline on the diagnosis and treatment of cardiomyopathies

H Kitaoka, H Tsutsui, T Kubo, T Ide, T Chikamori… - Circulation …, 2021 - jstage.jst.go.jp
The classes of recommendations and levels of evidence in these guidelines were
determined and described according to the “Guidelines for the treatment of acute and …

[HTML][HTML] Cardiac amyloidosis is prevalent in older patients with aortic stenosis and carries worse prognosis

JL Cavalcante, S Rijal, I Abdelkarim… - Journal of …, 2016 - Elsevier
Background Non-invasive cardiac imaging allows detection of cardiac amyloidosis (CA) in
patients with aortic stenosis (AS). Our objective was to estimate the prevalence of clinically …