Music as a unique source of noise-induced hearing loss

A Reynolds, EC Bielefeld - Hearing Research, 2023 - Elsevier
Music is among the most important artistic, cultural, and entertainment modalities in any
society. With the proliferation of music genres and the technological advances that allow …

The role of GABAB receptors in the subcortical pathways of the mammalian auditory system

R Tureček, A Melichar, M Králíková… - Frontiers in …, 2023 - frontiersin.org
GABAB receptors are G-protein coupled receptors for the inhibitory neurotransmitter GABA.
Functional GABAB receptors are formed as heteromers of GABAB1 and GABAB2 subunits …

[HTML][HTML] ERK1/2 Inhibition Alleviates Noise-Induced Hearing Loss While Tempering Down the Immune Response

RD Lutze, MA Ingersoll, A Thotam, A Joseph… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Noise-induced hearing loss (NIHL) is a major cause of hearing impairment, yet no FDA-
approved drugs exist to prevent it. Targeting the mitogen activated protein kinase (MAPK) …

A retrospective study of the effects of traumatic brain injury on auditory function: From a clinical perspective

M White, F Duquette-Laplante, B Jutras, C Bursch… - NeuroSci, 2022 - mdpi.com
Purpose: The main purpose of this retrospective study was to identify auditory dysfunctions
related to traumatic brain injury (TBI) in individuals evaluated in an Audiology clinic. Method …

C-Phycocyanin Attenuates Noise-Induced Cochlear Synaptopathy via the Inhibition of Oxidative Stress and Intercellular Adhesion Molecule-1 in the Cochlea

YC Lin, CP Shih, YY Lin, HC Lin, CY Kuo… - International Journal of …, 2024 - mdpi.com
The synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) are the
most vulnerable structures in the noise-exposed cochlea. Cochlear synaptopathy results …

In vitro characterization of novel hyaluronan-antioxidant conjugates as potential topical therapeutics against hearing loss

EM Arrigali, JGS Veit, B Birru, J Van Tine… - Frontiers in …, 2024 - frontiersin.org
Noise-induced hearing loss affects roughly 430 million people worldwide. Current treatment
options often require invasive medical procedures, and to date, there are no FDA-approved …

Integrating pharmacogenomics into clinical trials of hearing disorders

TP Brutnell, X Wang, J Bao - The Journal of the Acoustical Society of …, 2022 - pubs.aip.org
In 2019, the US Food and Drug Administration issued guidance to increase the efficiency of
drug development and support precision medicine, including tailoring treatments to those …

Unveiling the Role of Oxidative Stress in Cochlear Hair Cell Death: Prospective Phytochemical Therapeutics against Sensorineural Hearing Loss

NB Gill, PD Dowker-Key, M Hedrick… - International Journal of …, 2024 - mdpi.com
Hearing loss represents a multifaceted and pervasive challenge that deeply impacts various
aspects of an individual's life, spanning psychological, emotional, social, and economic …

ERK1/2 Inhibition via the Oral Administration of Tizaterkib Alleviates Noise-Induced Hearing Loss While Tempering down the Immune Response

RD Lutze, MA Ingersoll, A Thotam, A Joseph… - International Journal of …, 2024 - mdpi.com
Noise-induced hearing loss (NIHL) is a major cause of hearing impairment and is linked to
dementia and mental health conditions, yet no FDA-approved drugs exist to prevent it …

The Protective Effects of Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in Noise-Induced Hearing Loss of Rats

SY Kim, JE Lee, SH Kang, SM Lee, J Jeon, DR Lee - Cells, 2022 - mdpi.com
A few prior animal studies have suggested the transplantation or protective effects of
mesenchymal stem cells (MSCs) in noise-induced hearing loss. This study intended to …