The marine environment is an excellent source of molecules that have a wide structural
diversity and a variety of biological activities. Many marine natural products (MNPs) have …

A new series of nortopsentin analogs, in which the central imidazole ring of the natural lead
was replaced by a 1, 3, 4-oxadiazole or 1, 3, 4-thiadiazole moiety, was efficiently …

Proliferating cancer cells are characterized by the Warburg effect, a metabolic alteration in
which ATP is generated from cytoplasmic glycolysis instead of oxidative phosphorylation …

Breast cancer is a major threat to women's health worldwide. Although the 5-year survival
rate is relatively high, treating recurrent and metastatic breast cancer remains challenging …

Natural products as starting templates have shown historically major contribution to
development of drugs. Inspired by the structure–function of an anticancer natural alkaloid …

Tuberculosis, a persistent illness caused by Mycobacterium tuberculosis, remains a
significant global public health challenge. The widespread use of anti-tuberculosis drugs …

Despite improvements in overall cancer mortality, deaths related to pancreatic cancer
continue to rise. Following first-line treatment, second-line options are significantly limited …

Natural alkaloids originating from actinomycetes and synthetic derivatives have always been
among the important suppliers of small-molecule drugs. Among their biological sources …

Pancreatic cancer is one of the deadliest cancers with its highly aggressive and metastatic
character and there is a huge unmet need for new drugs treating pancreatic cancer. In the …

Purpose Oxidative stress promotes disease progression by stimulating the humoral and
cellular immune responses. However, the molecular mechanisms underlying oxidative …