Iron is an essential trace element for the human body, and its deficiency or excess can
induce a variety of biological processes. Plenty of evidences have shown that iron …

Acute or chronic cellular stress resulting from aberrant metabolic and biochemical processes
may trigger a pervasive non-apoptotic form of cell death, generally known as ferroptosis …

The concept of aging is complex, including many related phenotypes such as healthspan,
lifespan, extreme longevity, frailty and epigenetic aging, suggesting shared biological …

Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Iron is indispensable for normal body functions across species because of its critical roles in
red blood cell function and many essential proteins and enzymes required for numerous …

Abstract Background Satellite cells (SCs) are critical to skeletal muscle regeneration.
Inactivation of SCs is linked to skeletal muscle loss. Transferrin receptor 1 (Tfr1) is …

Objective This paper is a proposal for an update of the iron hypothesis of Alzheimer's
disease (AD), based on large‐scale emerging evidence. Background Iron featured …

Iron is a crucial element for mammalian cells, considering its intervention in several
physiologic processes. Its homeostasis is finely regulated, and its alteration could be …

Although it is clearly established that the abuse of alcohol is seriously harmful to health,
much epidemiological and clinical evidence seem to underline the protective role of …

DNA variants that modulate life span provide insight into determinants of health, disease,
and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program …