Immunoglobulin A (IgA) plays a key role in defending mucosal surfaces against attack by
infectious microorganisms. Such sites present a major site of susceptibility due to their vast …

With respect to biomanufacturing, glycosylation is one of the most addressed post-
translational modifications, since it is well-known that the attachment of sugar residues …

IgA antibodies have broad potential as a novel therapeutic platform based on their superior
receptor-mediated cytotoxic activity, potent neutralization of pathogens, and ability to …

The properties of host plants used for molecular farming can be modified by CRISPR/Cas9
genome editing to improve the quality and yield of recombinant proteins. However, it is often …

Human immunoglobulin A (IgA) is the most prevalent antibody class at mucosal sites with an
important role in mucosal defense. Little is known about the impact of N-glycan modifications …

Most secreted proteins in eukaryotes are glycosylated, and after a number of common
biosynthesis steps the glycan structures mature in a species-dependent manner. Therefore …

IgG, the main serum immunoglobulin isotype, exists in four subclasses which selectively
appear with distinctive glycosylation profiles. However, very little is known about the …

Background Expression of economically relevant proteins in alternative expression
platforms, especially plant expression platforms, has gained significant interest in recent …

Approximately 70% of recombinant therapeutic proteins are glycoproteins. They are playing
pivotal roles today in the treatment of an array of diseases. It is crucial for such proteins to be …

Plants express N-glycosylation pathways and produce N-glycosylated proteins but differ
from the mammalian-type proteins. Therefore attempts are made to design and engineer …