Ribosome biogenesis factors—from names to functions
K Dörner, C Ruggeri, I Zemp, U Kutay - The EMBO journal, 2023 - embopress.org
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
[HTML][HTML] mRNA vaccine development for emerging animal and zoonotic diseases
T Le, C Sun, J Chang, G Zhang, X Yin - Viruses, 2022 - mdpi.com
In the prevention and treatment of infectious diseases, mRNA vaccines hold great promise
because of their low risk of insertional mutagenesis, high potency, accelerated development …
because of their low risk of insertional mutagenesis, high potency, accelerated development …
[HTML][HTML] Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions
SL Yang, L DeFalco, DE Anderson, Y Zhang… - Nature …, 2021 - nature.com
SARS-CoV-2 is a major threat to global health. Here, we investigate the RNA structure and
RNA-RNA interactions of wildtype (WT) and a mutant (Δ382) SARS-CoV-2 in cells using …
RNA-RNA interactions of wildtype (WT) and a mutant (Δ382) SARS-CoV-2 in cells using …
RNA folding and functions of RNA helicases in ribosome biogenesis
V Mitterer, B Pertschy - RNA biology, 2022 - Taylor & Francis
Eukaryotic ribosome biogenesis involves the synthesis of ribosomal RNA (rRNA) and its
stepwise folding into the unique structure present in mature ribosomes. rRNA folding starts …
stepwise folding into the unique structure present in mature ribosomes. rRNA folding starts …
Lipid nanoparticles technology in vaccines: Shaping the future of prophylactic medicine
AAH Abdellatif, MA Younis, AF Alsowinea… - Colloids and Surfaces B …, 2023 - Elsevier
Throughout decades, the intrinsic power of the immune system to fight pathogens has
inspired researchers to develop techniques that enable the prevention or treatment of …
inspired researchers to develop techniques that enable the prevention or treatment of …
[HTML][HTML] From antisense RNA to RNA modification: therapeutic potential of RNA-based technologies
H Adachi, M Hengesbach, YT Yu, P Morais - Biomedicines, 2021 - mdpi.com
Therapeutic oligonucleotides interact with a target RNA via Watson-Crick complementarity,
affecting RNA-processing reactions such as mRNA degradation, pre-mRNA splicing, or …
affecting RNA-processing reactions such as mRNA degradation, pre-mRNA splicing, or …
Ribosomal RNA 2′-O-methylations regulate translation by impacting ribosome dynamics
S Khoshnevis, RE Dreggors-Walker… - Proceedings of the …, 2022 - National Acad Sciences
Protein synthesis by ribosomes is critically important for gene expression in all cells.
Ribosomal RNAs (rRNAs) are marked by numerous chemical modifications. An abundant …
Ribosomal RNAs (rRNAs) are marked by numerous chemical modifications. An abundant …
[HTML][HTML] NMR of RNA-structure and interactions
M Marušič, M Toplishek, J Plavec - Current Opinion in Structural Biology, 2023 - Elsevier
RNA was shown to have a more substantial role in the regulation of diverse cellular
processes than anticipated until recently. Answers to questions what is the structure of …
processes than anticipated until recently. Answers to questions what is the structure of …
Kinetic resolution of the atomic 3D structures formed by ground and excited conformational states in an RNA dynamic ensemble
Knowing the 3D structures formed by the various conformations populating the RNA free-
energy landscape, their relative abundance, and kinetic interconversion rates is required to …
energy landscape, their relative abundance, and kinetic interconversion rates is required to …
Chemical modifications to mRNA nucleobases impact translation elongation and termination
MK Franco, KS Koutmou - Biophysical chemistry, 2022 - Elsevier
Messenger RNAs (mRNAs) serve as blueprints for protein synthesis by the molecular
machine the ribosome. The ribosome relies on hydrogen bonding interactions between …
machine the ribosome. The ribosome relies on hydrogen bonding interactions between …