[HTML][HTML] NMR of RNA-structure and interactions
M Marušič, M Toplishek, J Plavec - Current Opinion in Structural Biology, 2023 - Elsevier
RNA was shown to have a more substantial role in the regulation of diverse cellular
processes than anticipated until recently. Answers to questions what is the structure of …
processes than anticipated until recently. Answers to questions what is the structure of …
Chemical modifications to mRNA nucleobases impact translation elongation and termination
MK Franco, KS Koutmou - Biophysical chemistry, 2022 - Elsevier
Messenger RNAs (mRNAs) serve as blueprints for protein synthesis by the molecular
machine the ribosome. The ribosome relies on hydrogen bonding interactions between …
machine the ribosome. The ribosome relies on hydrogen bonding interactions between …
Interplay of RNA 2′-O-methylations with viral replication
A Decombe, P El Kazzi, E Decroly - Current Opinion in Virology, 2023 - Elsevier
Highlights•Viral RNA genomes are modified by epitranscriptomic marks, such as 2′-O-
methylation.•2′-O-methylations are self-markers hijacked by viruses to avoid immune …
methylation.•2′-O-methylations are self-markers hijacked by viruses to avoid immune …
2′-O-Methyl modified guide RNA promotes the single nucleotide polymorphism (SNP) discrimination ability of CRISPR–Cas12a systems
Y Ke, B Ghalandari, S Huang, S Li, C Huang, X Zhi… - Chemical …, 2022 - pubs.rsc.org
The CRISPR–Cas12a system has been widely applied to genome editing and molecular
diagnostics. However, off-target cleavages and false-positive results remain as major …
diagnostics. However, off-target cleavages and false-positive results remain as major …
A quantitative model predicts how m6A reshapes the kinetic landscape of nucleic acid hybridization and conformational transitions
B Liu, H Shi, A Rangadurai, F Nussbaumer… - Nature …, 2021 - nature.com
ABSTRACT N 6-methyladenosine (m6A) is a post-transcriptional modification that controls
gene expression by recruiting proteins to RNA sites. The modification also slows …
gene expression by recruiting proteins to RNA sites. The modification also slows …
Direct Nanopore Sequencing for the 17 RNA Modification Types in 36 Locations in the E. coli Ribosome Enables Monitoring of Stress-Dependent Changes
The bacterium Escherichia coli possesses 16S and 23S rRNA strands that have 36 chemical
modification sites with 17 different structures. Nanopore direct RNA sequencing using a …
modification sites with 17 different structures. Nanopore direct RNA sequencing using a …
Beyond reader proteins: RNA binding proteins and RNA modifications in conversation to regulate gene expression
C Fagre, W Gilbert - Wiley Interdisciplinary Reviews: RNA, 2024 - Wiley Online Library
Post‐transcriptional mRNA modifications play diverse roles in gene expression and RNA
function. In many cases, RNA modifications function by altering how cellular machinery such …
function. In many cases, RNA modifications function by altering how cellular machinery such …
Internal RNA 2′-O-methylation on the HIV-1 genome impairs reverse transcription
A Decombe, O Peersen, P Sutto-Ortiz… - Nucleic Acids …, 2024 - academic.oup.com
Viral RNA genomes are modified by epitranscriptomic marks, including 2′-O-methylation
that is added by cellular or viral methyltransferases. 2′-O-Methylation modulates RNA …
that is added by cellular or viral methyltransferases. 2′-O-Methylation modulates RNA …
Oligonucleotide-based therapies for chronic HBV infection: a primer on biochemistry, mechanisms and antiviral effects
A Vaillant - Viruses, 2022 - mdpi.com
Three types of oligonucleotide-based medicines are under clinical development for the
treatment of chronic HBV infection. Antisense oligonucleotides (ASOs) and synthetic …
treatment of chronic HBV infection. Antisense oligonucleotides (ASOs) and synthetic …
Evaluating geometric definitions of stacking for RNA dinucleoside monophosphates using molecular mechanics calculations
A Taghavi, I Riveros, DJ Wales… - Journal of chemical theory …, 2022 - ACS Publications
RNA modulation via small molecules is a novel approach in pharmacotherapies, where the
determination of the structural properties of RNA motifs is considered a promising way to …
determination of the structural properties of RNA motifs is considered a promising way to …