Therapeutic oligonucleotides interact with a target RNA via Watson-Crick complementarity,
affecting RNA-processing reactions such as mRNA degradation, pre-mRNA splicing, or …

Thermodynamic propensities of biomolecules to adopt non-native conformations are crucial
for understanding how they function, but prove difficult to measure experimentally …

RNAs of all the domains of life carry chemical modifications. Extensive studies over the last
decades linked the loss of RNA modification enzymes to several pathologies, notably, ones …

During patho-physiological conditions, which lead to cell stress, there is a rapid and large
reduction in protein synthesis rates. This is mediated, in part, by a decrease in cap …

Ion mobility spectrometry–mass spectrometry (IMS-MS) has potential for the investigation of
structure and dynamics in large biopolymers, which will come to full fruition only with a firmer …

The review covers the progress in the field of NMR relaxation in fluids primarily during 2019.
Since the topic is returning to this volume SPR after a break of a few years, some highlights …

The structure and biological functions of the DNA double helix have been understood in the
light of Watson-Crick (WC) base pairs (bps). However, bps can adopt an alternative base …

Three types of oligonucleotide-based medicines are under clinical development for the
treatment of chronic HBV infection. Antisense oligonucleotides (ASOs) and synthetic …

Non-coding RNA (ncRNA) therapeutics are based on short oligonucleotides, both naturally
occurring and artificial, which target RNA in a site-specific way to modulate gene expression …

O-methylation (2'-O-Me), one of the most common modifications within RNA, has multiple
roles in modulating RNA structure, stability, and interactions, as well as gene transcription …