The effect of platelet-rich plasma on the intra-articular microenvironment in knee osteoarthritis

D Szwedowski, J Szczepanek, Ł Paczesny… - International Journal of …, 2021 - mdpi.com
Knee osteoarthritis (KOA) represents a clinical challenge due to poor potential for
spontaneous healing of cartilage lesions. Several treatment options are available for KOA …

Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?

AS Marchev, PA Dimitrova, AJ Burns… - Annals of the New …, 2017 - Wiley Online Library
Osteoarthritis (OA) is an age‐related joint degenerative disease associated with pain, joint
deformity, and disability. The disease starts with cartilage damage but then progressively …

Epigenetic changes in the pathogenesis of rheumatoid arthritis

MV Nemtsova, DV Zaletaev, IV Bure… - Frontiers in …, 2019 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects about 1% of the
world's population. The etiology of RA remains unknown. It is considered to occur in the …

Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy

P Singh, KB Marcu, MB Goldring… - Annals of the New York …, 2019 - Wiley Online Library
Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

[HTML][HTML] Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis

J Steinberg, GRS Ritchie, TI Roumeliotis… - Scientific reports, 2017 - nature.com
Osteoarthritis (OA) is a common disease characterized by cartilage degeneration and joint
remodeling. The underlying molecular changes underpinning disease progression are …

[HTML][HTML] Osteoarthritis year in review 2016: genetics, genomics and epigenetics

JBJ Van Meurs - Osteoarthritis and cartilage, 2017 - Elsevier
The purpose of this narrative review is to provide an overview of last year's publications in
the field of genetics, genomics and epigenetics in the osteoarthritis (OA) field. Major themes …

[HTML][HTML] Analysis of genetics and DNA methylation in osteoarthritis: what have we learnt about the disease?

LN Reynard - Seminars in Cell & Developmental Biology, 2017 - Elsevier
Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …

Role of epigenomics in bone and cartilage disease

JBJ van Meurs, CG Boer… - Journal of Bone and …, 2019 - academic.oup.com
Phenotypic variation in skeletal traits and diseases is the product of genetic and
environmental factors. Epigenetic mechanisms include information‐containing factors, other …

Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis

E Karouzakis, K Raza, C Kolling, CD Buckley, S Gay… - Scientific Reports, 2018 - nature.com
DNA methylation is an important epigenetic modification that is known to be altered in
rheumatoid arthritis synovial fibroblasts (RASF). Here, we compared the status of promoter …

Interaction between microRNA and DNA methylation in atherosclerosis

J Tao, L Xia, Z Cai, L Liang, Y Chen, J Meng… - DNA and Cell …, 2021 - liebertpub.com
Atherosclerosis (AS) is a chronic inflammatory disease accompanied by complex
pathological changes, such as endothelial dysfunction, foam cell formation, and vascular …