Increased reactive oxygen species (ROS) production has been detected in various cancers
and has been shown to have several roles, for example, they can activate pro-tumourigenic …

Abstract Calcium (Ca 2+) and reactive oxygen species (ROS) are versatile signaling
molecules coordinating physiological and pathophysiological processes. While channels …

NADPH oxidases (NOX) are enzyme complexes that have received much attention as key
molecules in the development of vascular dysfunction. NOX have the primary function of …

Oxidative stress has been implicated in the pathophysiology of diabetic nephropathy.
Studies in experimental animal models of diabetes strongly implicate oxidant species as a …

The Nrf2-Keap1-ARE pathway is the principal regulator of antioxidant and phase II
detoxification genes. Its activation increases the expression of antioxidant and cytoprotective …

Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …

Diabetes is a recognized risk factor for cardiovascular diseases and heart failure. Diabetic
cardiovascular dysfunction also underscores the development of diabetic retinopathy …

Diabetes is considered a major burden on the healthcare system of Western and non‐
Western societies with the disease reaching epidemic proportions globally. Diabetic patients …

Reactive oxygen species (ROS) generated by Nox NADPH oxidases may play a critical role
in the pathogenesis of diabetic nephropathy (DN). The efficacy of the Nox1/Nox4 inhibitor …

The NADPH oxidase (NOX) isoform NOX4 has been linked with diabetic kidney disease
(DKD). However, a mechanistic understanding of the downstream effects of NOX4 remains …