Despite advances in prostate cancer diagnosis and management, morbidity from prostate
cancer remains high. Approximately 20% of men present with advanced or metastatic …

Abstract In the United States, prostate cancer (PCa) is the most commonly diagnosed non-
cutaneous cancer in males and the second leading cause of cancer-related death for men …

Micro-ribonucleic acids (miRNAs) are important class of short regulatory RNA molecules
involved in regulation of several essential biological processes. In addition to Dicer and …

Prostate cancer (PCa) is the most widely diagnosed male cancer in the Western World and
while low-and intermediate-risk PCa patients have a variety of treatment options, metastatic …

Therapeutic interventions for advanced prostate cancer (PCa) center on inhibiting androgen
receptor (AR) and downstream signaling pathways. Resistance to androgen deprivation …

Despite aggressive treatment for localized cancer, prostate cancer (PC) remains a leading
cause of cancer-related death for American men due to a subset of patients progressing to …

Abstract Transgender individuals represent 0.55% of the US population, equivalent to 1.4
million transgender adults. In transgender women, feminisation can include a number of …

ABSTRACT AR (androgen receptor) signaling is crucial for the development and
maintenance of the prostate as well as the initiation and progression of prostate cancer …

Androgen deprivation therapy or ADT is one of the cornerstones of management of locally
advanced or metastatic prostate cancer, alongside radiation therapy. However, despite early …

SPAK (Ste20-related proline alanine rich kinase) and OSR1 (oxidative stress responsive
kinase) are members of the germinal center kinase VI subfamily of the mammalian Ste20 …