The Rec protein of HERV‐K (HML‐2) upregulates androgen receptor activity by binding to the human small glutamine‐rich tetratricopeptide repeat protein (hSGT)
K Hanke, C Chudak, R Kurth… - International journal of …, 2013 - Wiley Online Library
The expression of endogenous retroviruses of the HERV‐K (HML‐2) family is strongly
upregulated in germ cell tumors and several other cancers. Although the accessory Rec …
upregulated in germ cell tumors and several other cancers. Although the accessory Rec …
Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen
C Lupu, H Zhu, NI Popescu, JD Wren… - Blood, The Journal of …, 2011 - ashpublications.org
Thrombosis and cardiovascular disease (CVD) represent major causes of morbidity and
mortality. Low androgen correlates with higher incidence of CVD/thrombosis. Tissue Factor …
mortality. Low androgen correlates with higher incidence of CVD/thrombosis. Tissue Factor …
Multifunctionality of prostatic acid phosphatase in prostate cancer pathogenesis
E Alpert, A Akhavan, A Gruzman, WJ Hansen… - Bioscience …, 2021 - portlandpress.com
The role of human prostatic acid phosphatase (PAcP, P15309| PPAP_HUMAN) in prostate
cancer was investigated using a new proteomics tool termed signal sequence swapping …
cancer was investigated using a new proteomics tool termed signal sequence swapping …
Adaptation and clonal selection models of castration‐resistant prostate cancer: Current perspective
Prostate cancer is a leading cause of cancer deaths in men worldwide. Management of the
disease has remained a great challenge and even more so is the aggressive advanced …
disease has remained a great challenge and even more so is the aggressive advanced …
Food components and contaminants as (anti) androgenic molecules
Androgens, the main male sex steroids, are the critical factors responsible for the
development of the male phenotype during embryogenesis and for the achievement of …
development of the male phenotype during embryogenesis and for the achievement of …
Ailanthone: A novel potential drug for treating human cancer
H Ding, X Yu, C Hang, K Gao, X Lao… - Oncology …, 2020 - spandidos-publications.com
Cancer is the second leading cause of death after cardiovascular disease. In 2015,> 8.7
million people died worldwide due to cancer, and by 2030 this figure is expected to increase …
million people died worldwide due to cancer, and by 2030 this figure is expected to increase …
The impact of point mutations in the human androgen receptor: classification of mutations on the basis of transcriptional activity
CW Hay, IJ McEwan - PloS one, 2012 - journals.plos.org
Androgen receptor mediated signaling drives prostate cancer cell growth and survival.
Mutations within the receptor occur infrequently in prostate cancer prior to hormonal therapy …
Mutations within the receptor occur infrequently in prostate cancer prior to hormonal therapy …
Androgen receptor splice variants are resistant to inhibitors of Hsp90 and FKBP52, which alter androgen receptor activity and expression
AA Shafi, MB Cox, NL Weigel - Steroids, 2013 - Elsevier
Androgen ablation therapy is the most common treatment for advanced prostate cancer
(PCa), but most patients will develop castration-resistant prostate cancer (CRPC), which has …
(PCa), but most patients will develop castration-resistant prostate cancer (CRPC), which has …
Mechanisms of persistent activation of the androgen receptor in CRPC: recent advances and future perspectives
N Nadiminty, AC Gao - World journal of urology, 2012 - Springer
Background The emergence of castration resistance has remained the primary obstacle in
prostate cancer therapy for several decades. Mechanisms likely to be involved in castration …
prostate cancer therapy for several decades. Mechanisms likely to be involved in castration …
Method of treatment of prostate cancer with androgen receptor and glucocorticoid receptor antagonists
RZ Szmulewitz, SD Conzen - US Patent 9,289,436, 2016 - Google Patents
Methods are directed to the treatment of subjects with pros tate cancer, in particular those
with castration resistant pros tate cancer, with glucocorticoid receptor antagonists. The …
with castration resistant pros tate cancer, with glucocorticoid receptor antagonists. The …