Computational approaches for evaluation of isobavachin as potential inhibitor against t877a and w741l mutations in prostate cancer
Prostate cancer is the World's second most common cancer, with the fifth-highest male
mortality rate. Point mutations such as T877A and W741L are frequently seen in advanced …
mortality rate. Point mutations such as T877A and W741L are frequently seen in advanced …
Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers
D Adler, A Lindstrot, R Buettner… - … journal of molecular …, 2011 - spandidos-publications.com
Prostate cancer (PCA) is a clinically heterogeneous and often multifocal disease with a
clinical outcome difficult to predict. A deeper knowledge of the molecular basis of the …
clinical outcome difficult to predict. A deeper knowledge of the molecular basis of the …
[HTML][HTML] Androgen receptor mutations and polymorphisms in African American prostate cancer
S Koochekpour, E Buckles, M Shourideh… - … journal of biological …, 2014 - ncbi.nlm.nih.gov
The Androgen receptor (AR) plays a central role in the normal development of the prostate
gland, in prostate carcinogenesis, and in the progression of prostate cancer (PCa) to …
gland, in prostate carcinogenesis, and in the progression of prostate cancer (PCa) to …
[HTML][HTML] Baicalein suppresses the androgen receptor (AR)-mediated prostate cancer progression via inhibiting the AR NC dimerization and AR-coactivators interaction
D Xu, Q Chen, Y Liu, X Wen - Oncotarget, 2017 - ncbi.nlm.nih.gov
Background Androgen receptor (AR) plays a critical role in prostate cancer (PCa)
development and progression. Androgen deprivation therapy with antiandrogens to reduce …
development and progression. Androgen deprivation therapy with antiandrogens to reduce …
Aberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse
JW Kang, JP He, YN Liu, Y Zhang, SS Song… - Cellular and Molecular …, 2024 - Springer
The prostate is a vital accessory gonad in the mammalian male reproductive system. With
the ever-increasing proportion of the population over 60 years of age worldwide, the …
the ever-increasing proportion of the population over 60 years of age worldwide, the …
Flightless I homolog represses prostate cancer progression through targeting androgen receptor signaling
T Wang, W Song, Y Chen, R Chen, Z Liu, L Wu… - Clinical Cancer …, 2016 - AACR
Abstract Purpose: Flightless I (FLII), member of the gelsolin superfamily of actin-remodeling
proteins, functions as a transcriptional coregulator. We aim to evaluate a tumor-suppressive …
proteins, functions as a transcriptional coregulator. We aim to evaluate a tumor-suppressive …
A novel regulation of PSMA and PSA expression by Q640X AR in 22Rv1 and LNCaP prostate cancer cells
A Ben Jemaa, S Sallami, J Céraline… - Cell biology …, 2013 - Wiley Online Library
We have investigated the expression of prostate‐specific membrane antigen (PSMA) and
prostate‐specific antigen (PSA) transcripts in androgen‐dependent (LNCaP) and androgen …
prostate‐specific antigen (PSA) transcripts in androgen‐dependent (LNCaP) and androgen …
Molecular phenotyping of immune cells from young NOD mice reveals abnormal metabolic pathways in the early induction phase of autoimmune diabetes
J Wu, DN Kakoola, NI Lenchik, DM Desiderio… - 2012 - journals.plos.org
Islet leukocytic infiltration (insulitis) is first obvious at around 4 weeks of age in the NOD
mouse–a model for human type 1 diabetes (T1D). The molecular events that lead to insulitis …
mouse–a model for human type 1 diabetes (T1D). The molecular events that lead to insulitis …
Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression
AS Godoy, PC Sotomayor, M Villagran… - Biochemical and …, 2012 - Elsevier
Androgen receptor (AR) is required for the development and progression of prostate cancer
(CaP) from androgen-dependence to androgen-resistance. Both corepressors and …
(CaP) from androgen-dependence to androgen-resistance. Both corepressors and …
The Prospect of Identifying Resistance Mechanisms for Castrate‐Resistant Prostate Cancer Using Circulating Tumor Cells: Is Epithelial‐to‐Mesenchymal Transition a …
Prostate cancer (PCa) is initially driven by excessive androgen receptor (AR) signaling with
androgen deprivation therapy (ADT) being a major therapeutic approach to its treatment …
androgen deprivation therapy (ADT) being a major therapeutic approach to its treatment …