Emerging role of extracellular vesicles in the respiratory system

J Holtzman, H Lee - Experimental & Molecular Medicine, 2020 - nature.com
Extracellular vesicles (EVs) present numerous biomedical ways of studying disease and
pathology. They function as protective packaging for the delivery of controlled …

Mesenchymal stem cell-derived extracellular vesicles in therapy against fibrotic diseases

Y Huang, L Yang - Stem Cell Research & Therapy, 2021 - Springer
Fibrosis is likely to occur in many tissues and organs to induce cicatrisation and dysfunction.
The therapeutic regimens for delaying and even reversing fibrosis are quite limited at …

The mechanisms of cellular crosstalk between mesenchymal stem cells and natural killer cells: Therapeutic implications

M Moloudizargari, A Govahi, M Fallah… - Journal of Cellular …, 2021 - Wiley Online Library
Mesenchymal stem cells (MSCs) are mesenchymal precursors of various origins, with well‐
known immunomodulatory effects. Natural killer (NK) cells, the major cells of the innate …

Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles in COVID-19-induced ARDS: Mechanisms of action, research progress, challenges …

S Moradinasab, A Pourbagheri-Sigaroodi… - International …, 2021 - Elsevier
In late 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan city, Hubei province,
China. Rapidly escalated into a worldwide pandemic, it has caused an unprecedented and …

Role of mesenchymal stem cells and extracellular vesicles in idiopathic pulmonary fibrosis

S Kletukhina, G Mutallapova, A Titova… - International Journal of …, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial fibrotic disease that leads to
disability and death within 5 years of diagnosis. Pulmonary fibrosis is a disease with a …

Exosomal miR-107 antagonizes profibrotic phenotypes of pericytes by targeting a pathway involving HIF-1 α/Notch1/PDGFR β/YAP1/Twist1 axis in vitro

YC Wang, H Xie, YC Zhang, QH Meng… - American Journal …, 2021 - journals.physiology.org
Microvascular pericytes have been demonstrated as an origin for myofibroblasts that
produce excessive extracellular matrix (ECM) proteins such as α-smooth muscle actin (α …

Mesenchymal stem cell-derived exosomes: Characteristics and applications in disease pathology and management

H Padinharayil, J Varghese, C Wilson, A George - Life Sciences, 2024 - Elsevier
Mesenchymal stem cells (MSCs) possess a role in tissue regeneration and homeostasis
because of inherent immunomodulatory capacity and the production of factors that …

Dissecting the role of mesenchymal stem cells in idiopathic pulmonary fibrosis: cause or solution

AV Samarelli, R Tonelli, I Heijink… - Frontiers in …, 2021 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is one of the most aggressive forms of idiopathic
interstitial pneumonias, characterized by chronic and progressive fibrosis subverting the …

Mesenchymal stromal cell-derived extracellular vesicles restore thymic architecture and T cell function disrupted by neonatal hyperoxia

M Reis, GR Willis, A Fernandez-Gonzalez… - Frontiers in …, 2021 - frontiersin.org
Treating premature infants with high oxygen is a routine intervention in the context of
neonatal intensive care. Unfortunately, the increase in survival rates is associated with …

Therapeutic potential of exosomes in pulmonary fibrosis

L Xie, Y Zeng - Frontiers in Pharmacology, 2020 - frontiersin.org
Pulmonary fibrosis is closely associated with the recruitment of fibroblasts from capillary
vessels with damaged endothelial cells, the epithelial mesenchymal transition (EMT) of type …