Aging, defined as the gradual alteration in structure and function that occurs over time,
eventually leads to increased probability of nondisease-or nontrauma-related death [1] …

Proteomics, the characterization of the proteome, is conceptually simple but technically
challenging. Development of such technologies as mass spectrometry, multidimensional …

Proteomics have long been applied into characterization of molecular signatures in aging.
Due to different methods and instrumentations employed for proteomic analysis, inter …

Extended longevity is often accompanied by frailty and increased susceptibility to a variety of
crippling disorders. One of the most striking features of human aging is sarcopenia, which is …

The function of a protein is modulated by its abundance and its degree of specific post‐
translational modifications such as phosphorylation, glycosylation or truncation …

In contrast to the traditional biochemical study of single proteins or isolated pathways in
health and disease, technical advances in the high-throughput screening of peptides by …

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蛋白组分析是对生物蛋白组的分析与检测, 即对生物蛋白质的大范围研究. 蛋白组分析首先要将
混合蛋白质分离, 分离的主要方法是蛋白双向电泳. 蛋白双向电泳是一种高效且广泛应用于分析 …

Background Aging is broadly considered to be a dynamic process that accumulates
unfavourable structural and functional changes in a time dependent fashion, leading to a …

The scope of the current paper is to review existing and potential applications of proteomic
analysis to aging research. The focus will lie on the unique opportunities of high-throughput …