Neurons depend on mitochondrial functions for membrane excitability, neurotransmission,
and plasticity. Mitochondrial dynamics are important for neural cell maintenance. To …

Neurodegenerative diseases (NDDs) like Alzheimer's disease (AD), Parkinson's disease
(PD), and amyotrophic lateral sclerosis (ALS) are defined by a myriad of complex …

Autophagy mediates self-digestion of abnormally aggregated proteins and organelles
present in the cytoplasm. This mechanism may prove to be neuroprotective against …

Parkinson's disease (PD) is characterized by the formation of Lewy body in dopaminergic
neurons in the substantia nigra pars compacta (SNpc). Alpha-synuclein (α-syn) is a major …

Alzheimer's disease (AD) is a disorder of the central nervous system that is typically marked
by progressive cognitive impairment and memory loss. Amyloid β plaque deposition and …

Macroautophagy, herein referred to as autophagy, has long been implicated in the
pathophysiology of neurodegenerative diseases. However, an incomplete understanding of …

Mitochondria play a key role in regulating host metabolism, immunity and cellular
homeostasis. Remarkably, these organelles are proposed to have evolved from an …

With technological applications, especially in genetic testing, new diseases have been
discovered and new disease concepts have been proposed in recent years; however, the …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, of the so-
called minority diseases, due to its low prevalence. It is caused by an abnormally long track …

The lifelong maintenance of cognitive abilities in an increasingly aging human society is one
of the major challenges of future research and medical services. For this, a better …