Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

Myelinated nerve fibers have evolved to enable fast and efficient transduction of electrical
signals in the nervous system. To act as an electric insulator, the myelin sheath is formed as …

Oligodendrocyte precursor cells (OPCs) account for 5% of the resident parenchymal central
nervous system glial cells. OPCs are not only a back-up for the loss of oligodendrocytes that …

Myelination of axons in the nervous system of vertebrates enables fast, saltatory impulse
propagation, one of the best-understood concepts in neurophysiology. However, it took a …

Structured illumination microscopy (SIM) doubles the spatial resolution of a fluorescence
microscope without requiring high laser powers or specialized fluorophores. However, the …

Myelin sheaths provide critical functional and trophic support for axons in white matter tracts
of the brain. Oligodendrocyte precursor cells (OPCs) have extraordinary metabolic …

The wrapping of multiple layers of myelin membrane sheets around an axon is of
fundamental importance for the function of the nervous system. In the central nervous system …

A protein undergoes many types of posttranslation modification. Citrullination is one of these
modifications, where an arginine amino acid is converted to a citrulline amino acid. This …

The integrity of central and peripheral nervous system myelin is affected in numerous lipid
metabolism disorders. This vulnerability was so far mostly attributed to the extraordinarily …

The efficiency of central nervous system remyelination declines with age. This is in part due
to an age-associated decline in the phagocytic removal of myelin debris, which contains …