General anesthetics are known to transiently increase the expression of messenger
ribonucleic acids (mRNAs) of immediate-early genes in the brain. We investigated whether …

Therapy for ischemic heart disease has been directed traditionally at limiting cell necrosis.
We determined by genome profiling whether ischemic myocardium can trigger a genetic …

Protein phosphorylation acts a pivotal mechanism in regulating the contractile state of the
heart by modulating particular levels of autonomic control on cardiac force/length …

MicroRNA‐27a (miR‐27a) has been implicated in myocardial ischemia‐reperfusion injury
(MIRI), but the underlying mechanism is not well understood. This study is aimed at …

In response to hypoxia and reoxygenation, mammalian cells are known to express a variety
of genes to adapt to these external stresses or lead to further cell damage. We investigated …

Despite improved treatment options myocardial infarction (MI) is still a leading cause of
mortality and morbidity worldwide. Remote ischemic preconditioning (RIPC) is a mechanistic …

Background and aims: The cellular and molecular events involved in ischaemia reperfusion
(IR) injury are complex and not fully understood. Previous studies have implicated …

Abstract Matrix metalloproteinase‐13 (MMP‐13) is involved in the degradation of
extracellular matrix in many kinds of tissues. Here we found that hypoxia increased MMP‐13 …

Lyn, Deborah, Xiaowei Liu, Nicole A. Bennett, and Nerimiah L. Emmett. Gene expression
profile in mouse myocardium after ischemia. Physiol Genomics 2: 93–100, 2000.—This …

This review will focus on the free radical signaling mechanism of preconditioning. The
results from our laboratory as well as studies from other laboratories suggest that reactive …