Early growth response gene-1 suppresses foot-and-mouth disease virus replication by enhancing type I interferon pathway signal transduction

Z Zhu, X Du, P Li, X Zhang, F Yang, W Cao… - Frontiers in …, 2018 - frontiersin.org
Early growth response gene-1 (EGR1) is a multifunctional transcription factor that is
implicated in viral infection. In this study, we observed that foot-and-mouth disease virus …

Mitogen‐activated protein kinases and anoxia tolerance in turtles

SC Greenway, KB Storey - Journal of Experimental Zoology, 2000 - Wiley Online Library
The response of two vertebrate mitogen‐activated protein kinase (MAPK) family members,
the extracellular signal‐regulated kinases (ERKs) and c‐Jun NH2‐terminal kinases (JNKs) …

Heme oxygenase and cardiac function in ischemic/reperfused rat hearts

C Csonka, E Varga, P Kovacs, P Ferdinandy… - Free Radical Biology …, 1999 - Elsevier
We investigated whether the expression of heme oxygenase (HO) isozymes was related to
the occurrence of ventricular fibrillation (VF) induced by ischemia/reperfusion in nondiabetic …

Mitogen-activated protein kinase translocates to the nucleus during ischaemia and is activated during reperfusion

Y MIZUKAMI, K YOSHIDA - Biochemical Journal, 1997 - portlandpress.com
Growth factors and various cellular stresses are known to activate mitogen-activated protein
(MAP) kinase, which plays a role in conveying signals from the cytosol to the nucleus. The …

DNAzymes and cardiovascular disease

VL Benson, LM Khachigian… - British journal of …, 2008 - Wiley Online Library
Gene silencing techniques are gaining increasing popularity in the literature, both as a tool
for unravelling gene function and to potentially deliver therapeutic benefit, especially in the …

Role of early growth response 1 in arteriogenesis: impact on vascular cell proliferation and leukocyte recruitment in vivo

JI Pagel, T Ziegelhoeffer, M Heil… - Thrombosis and …, 2012 - thieme-connect.com
Based on previous findings that early growth response 1 (Egr-1) participates in leukocyte
recruitment and cell proliferation in vitro, this study was designed to investigate its mode of …

Nuclear mitogen-activated protein kinase activation by protein kinase Cζ during reoxygenation after ischemic hypoxia

Y Mizukami, S Kobayashi, F Uberall, K Hellbert… - Journal of Biological …, 2000 - ASBMB
We examined the upstream kinases for mitogen-activated protein kinase (MAPK) activation
during ischemic hypoxia and reoxygenation using H9c2 cells derived from rat …

Altered gene expression during hypoxia and reoxygenation of the heart

L Piacentini, JS Karliner - Pharmacology & therapeutics, 1999 - Elsevier
The heart is exposed to alterations in oxygen tension under different pathophysiological
conditions. In order to maintain function, changes in the pattern of cardiac gene expression …

Hyperinsulinemic normoglycemia does not meaningfully improve myocardial performance during cardiac surgery: a randomized trial

AE Duncan, B Kateby Kashy, S Sarwar, A Singh… - …, 2015 - pubs.asahq.org
Abstract Background: Glucose–insulin–potassium (GIK) administration during cardiac
surgery inconsistently improves myocardial function, perhaps because hyperglycemia …

Early Growth Response 1 Contributes to Renal IR Injury by Inducing Proximal Tubular Cell Apoptosis

K Jeong, J Je, T Dusabimana, H Kim… - International Journal of …, 2023 - mdpi.com
Renal ischemia–reperfusion (IR) causes acute kidney injury due to oxidative stress, tubular
inflammation, and apoptosis. Early growth response 1 (Egr-1) is a transcription factor …