Increased hepatic gluconeogenesis and type 2 diabetes mellitus
Abnormally increased hepatic gluconeogenesis is a significant contributor to hyperglycemia
in the fasting state in patients with type 2 diabetes mellitus (T2DM) due to insulin resistance …
in the fasting state in patients with type 2 diabetes mellitus (T2DM) due to insulin resistance …
Revisiting liver metabolism through acetyl-CoA carboxylase inhibition
AJ Pérez-Díaz, MÁ Núñez-Sánchez… - Trends in Endocrinology …, 2024 - cell.com
Liver-targeted acetyl-coenzyme A (CoA) carboxylase (ACC) inhibitors in metabolic
dysfunction-associated steatotic liver disease (MASLD) trials reveal notable secondary …
dysfunction-associated steatotic liver disease (MASLD) trials reveal notable secondary …
Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses
Q Cai, Y Tian, QTH Shubhra - Cell Metabolism, 2024 - Elsevier
Tumors compromise T cell functionality through various mechanisms, including the induction
of a nutrient-scarce microenvironment, leading to lipid accumulation and metabolic …
of a nutrient-scarce microenvironment, leading to lipid accumulation and metabolic …
Valine and Inflammation Drive Epilepsy in a Mouse Model of ECHS1 Deficiency
MM Eller, AR Zuberi, X Fu, SC Burgess, CM Lutz… - bioRxiv, 2024 - biorxiv.org
ECHS1 Deficiency (ECHS1D) is a rare and devastating pediatric disease that currently has
no defined treatments. This disorder results from missense loss-of-function mutations in the …
no defined treatments. This disorder results from missense loss-of-function mutations in the …