Chemically engineering cells for precision medicine
Y Wang, Z Li, F Mo, TJ Chen-Mayfield, A Saini… - Chemical Society …, 2023 - pubs.rsc.org
Cell-based therapy holds great potential to address unmet medical needs and revolutionize
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …
[HTML][HTML] Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities
B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …
endogenous characteristics, however, further bioengineering refinement is required to …
Immunogenic PANoptosis‐Initiated Cancer Sono‐Immune Reediting Nanotherapy by Iteratively Boosting Cancer Immunity Cycle
L Zhou, J Lyu, F Liu, Y Su, L Feng… - Advanced …, 2024 - Wiley Online Library
The cancer‐immune cycle conceptualized the mechanisms of driving T cell responses to
tumors, but w as limited by immunological ignorance elicited by tumor inherent …
tumors, but w as limited by immunological ignorance elicited by tumor inherent …
Cell‐specific targeting of extracellular vesicles through engineering the glycocalyx
W Zheng, R He, X Liang, S Roudi, J Bost… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are promising carriers for the delivery of a variety of chemical
and biological drugs. However, their efficacy is limited by the lack of cellular specificity …
and biological drugs. However, their efficacy is limited by the lack of cellular specificity …
Engineered extracellular vesicles for bone therapy
Extracellular vesicles, which are secreted by living cells and play a critical role in cellular
communication, have emerged as a promising cell-free strategy in the treatment of many …
communication, have emerged as a promising cell-free strategy in the treatment of many …
[HTML][HTML] Extracellular vesicles as bioactive nanotherapeutics: an emerging paradigm for regenerative medicine
In recent decades, extracellular vesicles (EVs), as bioactive cell-secreted nanoparticles
which are involved in various physiological and pathological processes including cell …
which are involved in various physiological and pathological processes including cell …
[HTML][HTML] Therapeutic potential of exosome‐based personalized delivery platform in chronic inflammatory diseases
C Wang, M Xu, Q Fan, C Li, X Zhou - Asian journal of pharmaceutical …, 2023 - Elsevier
In the inflammatory microenvironment, there are numerous exosomes secreted by immune
cells (Macrophages, neutrophils, dendritic cells), mesenchymal stem cells (MSCs) and …
cells (Macrophages, neutrophils, dendritic cells), mesenchymal stem cells (MSCs) and …
[HTML][HTML] Engineering stem cells to produce exosomes with enhanced bone regeneration effects: an alternative strategy for gene therapy
Background Exosomes derived from stem cells have been widely studied for promoting
regeneration and reconstruction of multiple tissues as “cell-free” therapies. However, the …
regeneration and reconstruction of multiple tissues as “cell-free” therapies. However, the …
[HTML][HTML] Engineering exosome-based biomimetic nanovehicles for wound healing
A Joorabloo, T Liu - Journal of Controlled Release, 2023 - Elsevier
Complexity and difficulties in wound management are pressing concerns that affect patients'
quality of life and may result in tissue infection, necrosis, and loss of local and systemic …
quality of life and may result in tissue infection, necrosis, and loss of local and systemic …
[HTML][HTML] Immune cell-derived extracellular vesicles–new strategies in cancer immunotherapy
P Yang, Y Peng, Y Feng, Z Xu, P Feng, J Cao… - Frontiers in …, 2021 - frontiersin.org
Immune cell-derived extracellular vesicles (EVs) have increasingly become the focus of
research due to their unique characteristics and bioinspired applications. They are lipid …
research due to their unique characteristics and bioinspired applications. They are lipid …