This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Salt and fluid absorption and secretion are two processes that are fundamental to epithelial
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …

Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR) gene that impair the function of CFTR, an epithelial chloride channel required for …

Abstract Background Ivacaftor (KALYDECO™, VX-770) is a CFTR potentiator that increased
CFTR channel activity and improved lung function in patients age 6 years and older with CF …

Ion channels play fundamental roles in both excitable and non-excitable tissues and
therefore constitute attractive drug targets for myriad neurological, cardiovascular and …

Abstract Systems analysis has historically been performed in many areas of biology,
including ecology, developmental biology and immunology. More recently, the genomics …

Cytotoxic brain edema triggered by neuronal swelling is the chief cause of mortality
following brain trauma and cerebral infarct. Using fluorescence lifetime imaging to analyze …

Chloride is the principal anion in the extracellular fluid and is the second main contributor to
plasma tonicity. Its concentration is frequently abnormal in intensive care unit patients, often …