Transient receptor potential vanilloid subtype 1 (TRPV1) is a polymodal nociceptor that
monitors noxious thermal sensations. Few studies have addressed the role of TRPV1 in …

Neuropathic pain is more prevalent in women. However, females are under-represented in
animal experiments, and the mechanisms of sex differences remain inadequately …

Head and neck squamous cell carcinoma (HNSCC) patients report severe function-induced
pain at the site of the primary tumor. The current hypothesis is that oral cancer pain is …

The loss of GABAergic inhibition is a mechanism that underlies neuropathic pain. Therefore,
rescuing the GABAergic inhibitory tone through the activation of GABA A receptors is a …

PKC and PKA phosphorylation inhibit TREK‐1 channels downstream of Gs protein‐coupled
receptor activation in vitro. However, the role of phosphorylation of TREK‐1 in neuropathic …

Background Sex plays a crucial role in pain processing and response to analgesic drugs.
Indeed, spinal glia seems to be significant in the sexual dimorphism observed in the above …

The purpose of this study is to investigate the role of microRNA‐125b (miR‐125b) and its
mechanism in spinal cord injury (SCI) by targeting Smurf1. After loss‐and gain‐function …

Peripheral neurons are heterogeneous and functionally diverse, but all share the capability
to switch to a pro-regenerative state after nerve injury. Despite the assumption that the injury …

Previous studies have reported that L5/L6 spinal nerve ligation (SNL), but not L5 spinal
nerve transection (SNT), enhances anoctamin-1 in injured and uninjured dorsal root ganglia …

Background Skin denervation that develops in patients with diabetes mellitus as a
neuropathic manifestation is known as diabetic peripheral neuropathy (DPN). Skin …