Injectable microfluidic hydrogel microspheres for cell and drug delivery

Z Zhao, Z Wang, G Li, Z Cai, J Wu… - Advanced Functional …, 2021 - Wiley Online Library
Microfluidic hydrogel microspheres have been broadly studied across a wide range of
industries and applications, and their use in the medical field, including control cells and …

[HTML][HTML] Enzymatic hydrolysis and microbial fermentation: The most favorable biotechnological methods for the release of bioactive peptides

DE Cruz-Casas, CN Aguilar, JA Ascacio-Valdés… - Food Chemistry …, 2021 - Elsevier
Bioactive peptides are biomolecules derived from proteins. They contain anywhere from 2 to
20 amino acids and have different bioactivities. For example, they have antihypertensive …

[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Q Zhu, Z Chen, PK Paul, Y Lu, W Wu, J Qi - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

[HTML][HTML] Biocompatibility, biodegradation and biomedical applications of poly (lactic acid)/poly (lactic-co-glycolic acid) micro and nanoparticles

EM Elmowafy, M Tiboni, ME Soliman - Journal of Pharmaceutical …, 2019 - Springer
Background Poly (lactic acid)(PLA) and poly (lactic-co-glycolic acid)(PLGA) are among the
well-documented FDA-approved polymers used for the preparation of safe and effective …

[HTML][HTML] Physicochemical properties of mucus and their impact on transmucosal drug delivery

J Leal, HDC Smyth, D Ghosh - International journal of pharmaceutics, 2017 - Elsevier
Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …

[HTML][HTML] Thin films as an emerging platform for drug delivery

S Karki, H Kim, SJ Na, D Shin, K Jo, J Lee - asian journal of pharmaceutical …, 2016 - Elsevier
Pharmaceutical scientists throughout the world are trying to explore thin films as a novel
drug delivery tool. Thin films have been identified as an alternative approach to conventional …

Encapsulation, protection, and delivery of bioactive proteins and peptides using nanoparticle and microparticle systems: A review

DJ McClements - Advances in colloid and interface science, 2018 - Elsevier
There are many examples of bioactive proteins and peptides that would benefit from oral
delivery through functional foods, supplements, or medical foods, including hormones …

[HTML][HTML] Nanoparticles: oral delivery for protein and peptide drugs

S Cao, S Xu, H Wang, Y Ling, J Dong, R Xia, X Sun - Aaps Pharmscitech, 2019 - Springer
Protein and peptide drugs have many advantages, such as high bioactivity and specificity,
strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of …

An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers

Y Xu, N Shrestha, V Préat, A Beloqui - Advanced Drug Delivery Reviews, 2021 - Elsevier
Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …

[HTML][HTML] Peptides with dual antimicrobial and anticancer activities

MR Felício, ON Silva, S Gonçalves, NC Santos… - Frontiers in …, 2017 - frontiersin.org
In recent years, the number of people suffering from cancer and multi-resistant infections has
increased, such that both diseases are already seen as current and future major causes of …