Liposomes are being increasingly utilized to deliver drugs, enzymes, antisense
oligonucleotides, and genes to various therapeutic targets. Liposome-mediated delivery of …

Introduction Polyamines (putrescine, spermidine and spermine) are ubiquitous polycationic
metabolites in prokaryotic and eukaryotic cells. Their roles in the regulation of major …

The application of cationic liposome reagents has advanced DNA and mRNA transfection
research in vitro, and data are accumulating which show their utility for in vivo gene transfer …

Disclosed are cationic lipids capable of facilitating transport of biologically active agents into
cells, including the transfection of cells by therapeutic polynucleotides, the delivery of …

0 [1*] N ([2*])([3*]) CC (COCCCCC/C= C\C/C= C\C/C= C\C [4*]) OCCCCC/C= C\C/C=
C\C/C= C\C [5*] Chemical compound [1*] N ([2*])([3*]) CC (COCCCCC/C= C\C/C= C\C/C …

The present invention provides novel, stable lipid particles comprising one or more active
agents or therapeutic agents, methods of making the lipid particles, and methods of deliv …

US7799565B2 - Lipid encapsulated interfering RNA - Google Patents US7799565B2 - Lipid
encapsulated interfering RNA - Google Patents Lipid encapsulated interfering RNA …

The present invention provides novel cationic lipids that have increased flexibility over
commonly used cationic lipids (such as DODAC and DODMA). When incorporated into lipid …

Disclosed are cationic lipids capable of facilitating transport of biologically active agents into
cells, including the transfection of cells by therapeutic polynucleotides, the delivery of …

A method is disclosed for delivering an isolated polynucleotide to the interior of a cell in a
vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue …