Translating results from pre-clinical animal studies to successful human clinical trials in
neurodegenerative and neuropsychiatric disease presents a significant challenge. While …

The accumulation of senescent cells contributes to aging pathologies, including
neurodegenerative diseases, and its selective removal improves physiological and cognitive …

Most patients with Alzheimer's disease (AD) develop neuropsychiatric symptoms (NPS)
alongside cognitive decline, and apathy is one of the most common symptoms. Few …

Despite considerable advances in both in silico and in vitro approaches, in vivo studies that
involve animal model systems remain necessary in many research disciplines …

With the growing popularity of touchscreen cognitive testing in rodents, it is imperative to
understand the fundamental effects exposure to this paradigm can have on the animals …

While Alzheimer's disease (AD) is traditionally associated with deficits in episodic memory,
early changes in other cognitive domains, such as attention, have been gaining interest. In …

Background Alzheimer's disease (AD) is characterized by physiologically endogenous
proteins amyloid beta (Aβ) and tau undergoing a conformational change and accumulating …

A critical challenge in current research on Alzheimer's disease (AD) is to clarify the
relationship between network dysfunction and the emergence of subtle memory deficits in …

Tubulin-associated unit (Tau) is a microtubule-associated protein, whose abnormal
phosphorylation and deposition in the brain characterizes a range of neurodegenerative …

Spontaneous recognition memory tasks are widely used to assess cognitive function in
rodents and have become commonplace in the characterization of rodent models of …