Key Clinical Points Primary Ovarian Insufficiency Primary ovarian insufficiency should be
considered in women younger than 40 years of age who present with new-onset irregular …

As one of the problems and diseases for women before 40 years, premature ovarian failure
(POF) could be characterized by amenorrhea, low estrogen levels, infertility, high …

卵巢早衰(premature ovarian failure, POF) 是指妇女在40 岁以前因某种原因引起的闭经, 不育,
雌激素缺乏, 以及促性腺激素水平升高为特征的一种疾病. 文献报道, 40 岁以前卵巢早衰发生率 …

Objective: The objective of this document is to generate a practice guideline for the
management and treatment of symptoms of the menopause. Participants: The Treatment of …

In women, the non-growing population of follicles that comprise the ovarian reserve is
determined at birth and serves as the reservoir for future fertility. This reserve of dormant …

Premature ovarian failure (POF) causing hypergonadotrophic hypogonadism occurs in 1%
of women. In majority of cases the underlying cause is not identified. The known causes …

The genetic analysis of life span has only begun in mammals, invertebrates, such as
Caenorhabditis elegans and Drosophila, and yeast. Even at this primitive stage of the …

Normal menopause is associated with vascular endothelial dysfunction, an early stage of
atherosclerosis. The effect of premature ovarian failure (or premature menopause) on …

Granulosa cells are essential for follicle initiation and development, and their abnormal
function or apoptosis is a crucial factor leading to follicular atresia. A state of oxidative stress …

An increasing number of options are available for women who wish to preserve their fertility,
particularly before cancer treatment: oophorectomy with cryopreservation, embryo …