The triad of nanotechnology, cell signalling, and scaffold implantation for the successful repair of damaged organs: An overview on soft-tissue engineering

P Abdollahiyan, F Oroojalian… - Journal of controlled …, 2021 - Elsevier
As a milestone in therapeutic fields, tissue engineering has offered an alternative strategy to
address unmet clinical needs for the repair and replacement of human damaged organs …

Adverse cardiovascular effects and potential molecular mechanisms of DEHP and its metabolites—a review

ZJ Wen, ZY Wang, YF Zhang - Science of The Total Environment, 2022 - Elsevier
Currently, cardiovascular disease (CVD) is a health hazard that is associated with
progressive deterioration upon exposure to environmental pollutants. Di (2-ethylhexyl) …

[HTML][HTML] Utility of iPSC-derived cells for disease modeling, drug development, and cell therapy

MW Nicholson, CY Ting, DZH Chan, YC Cheng… - Cells, 2022 - mdpi.com
The advent of induced pluripotent stem cells (iPSCs) has advanced our understanding of the
molecular mechanisms of human disease, drug discovery, and regenerative medicine. As …

Effects of electrically conductive nano-biomaterials on regulating cardiomyocyte behavior for cardiac repair and regeneration

M Morsink, P Severino, E Luna-Ceron, MA Hussain… - Acta biomaterialia, 2022 - Elsevier
Myocardial infarction (MI) represents one of the most prevalent cardiovascular diseases,
with a highly relevant and impactful role in public health. Despite the therapeutic advances …

Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it

S Nattel, PT Sager, J Hueser, J Heijman… - Cardiovascular …, 2021 - academic.oup.com
Atrial fibrillation (AF) is the most common sustained clinical arrhythmia, with a lifetime
incidence of up to 37%, and is a major contributor to population morbidity and mortality …

[HTML][HTML] Modeling hypertrophic cardiomyopathy with human cardiomyocytes derived from induced pluripotent stem cells

J Li, X Feng, X Wei - Stem Cell Research & Therapy, 2022 - Springer
One of the obstacles in studying the pathogenesis of hypertrophic cardiomyopathy (HCM) is
the poor availability of myocardial tissue samples at the early stages of disease …

Development and characterization of furfuryl-gelatin electrospun scaffolds for cardiac tissue engineering

N Nagiah, R El Khoury, MH Othman, J Akimoto, Y Ito… - Acs Omega, 2022 - ACS Publications
In this study, three types of electrospun scaffolds, including furfuryl-gelatin (f-gelatin) alone, f-
gelatin with polycaprolactone (PCL) in a 1: 1 ratio, and coaxial scaffolds with PCL (core) and …

Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy

RJ Phang, RH Ritchie, DJ Hausenloy… - Cardiovascular …, 2023 - academic.oup.com
Patients with Type 2 diabetes mellitus (T2DM) frequently exhibit a distinctive cardiac
phenotype known as diabetic cardiomyopathy. Cardiac complications associated with T2DM …

[HTML][HTML] Advances in 3D organoid models for stem cell-based cardiac regeneration

M Martin, EKN Gähwiler, M Generali… - International Journal of …, 2023 - mdpi.com
The adult human heart cannot regain complete cardiac function following tissue injury,
making cardiac regeneration a current clinical unmet need. There are a number of clinical …

Deciphering pathogenicity of variants of uncertain significance with CRISPR-edited iPSCs

H Guo, L Liu, M Nishiga, L Cong, JC Wu - Trends in Genetics, 2021 - cell.com
Genetic variants play an important role in conferring risk for cardiovascular diseases (CVDs).
With the rapid development of next-generation sequencing (NGS), thousands of genetic …