It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

Oxidative stress (OS) due to an imbalance between reactive oxygen species (ROS) and
antioxidants has been established as an important factor that can negatively affect the …

In brief Reactive oxygen species are generated throughout the pre-implantation period and
are necessary for normal embryo formation. However, at pathological levels, they result in …

Ovarian aging leads to a decrease in the quantity and quality of oocytes. Aged oocytes have
significantly reduced amounts of mitochondria, the energy factories of cells, leading to lower …

Resveratrol is one of the most investigated natural polyphenolic compounds and is
contained in more than 70 types of plants and in red wine. The widespread interest in this …

An increase in intraovarian reactive oxygen species (ROS) has long been implicated in the
decline in oocyte quality associated with maternal ageing. Oxidative stress (OS)-induced …

The objective of this work was to determine the role of mitochondria in the loss of oocyte
quality with maternal aging. Our results show that mitochondrial DNA (mtDNA) copy number …

STUDY QUESTION What is the effect of three antioxidants (acetyl-L-carnitine, N-acetyl-L-
cysteine and α-lipoic acid), when used individually and in combination, on mouse embryo …

Approximately, 10–15% of women of reproductive age are affected by endometriosis, which
often leads to infertility. Endometriosis often has an inherited component, and several …

STUDY QUESTION Does the oxygen concentration in the culture medium [either physiologic
(5%) or atmospheric (20%)] affect mitochondrial ultrastructure and function in …