Enormous interest has emerged in the perioperative use of high concentrations of inspired
oxygen in an attempt to increase tissue oxygenation and thereby improve postoperative …

Acute kidney injury (AKI) is associated with significant mortality, which increases further
when combined with acute lung injury. Experiments in rodents have shown that kidney …

Pathological formation of reactive oxygen species within the coronary circulation has been
hypothesized to mediate some clinical manifestations of ischemic heart disease (IHD) by …

Anaesthesia management of patients with airway susceptibility remains a challenge in daily
clinical practice due to the increased risk of perioperative bronchospasm. Therefore …

Hyperoxia can cause substantial reductions in peripheral and coronary blood flow at rest
and during exercise, which may be caused by reactive oxygen species (ROS) generated …

Ambrisentan, an endothelin receptor type A antagonist, may be a novel therapeutic agent in
neonatal chronic lung disease (CLD) by blocking the adverse effects of the vasoconstrictor …

The available treatment strategies against pulmonary hypertension include the
administration of endothelin‐1 (ET‐1) receptor subtype blockers (ETA and ETB antagonists); …

Background The patient population receiving long-term oxygen therapy has increased with
the rising morbidity of COPD. Although high-dose oxygen induces pulmonary edema and …

Objective Hyperoxia exposure leads to the development of lung injury and bronchial
hyperreactivity (BHR) via involvement of nitric oxide (NO) pathway. We aimed at …