Therapeutic drug monitoring (TDM) should be adopted in all neonatal intensive care units
(NICUs), where the most preterm and fragile babies are hospitalized and treated with many …

Due to complex maturational and physiological changes that characterize neonates and
affect their response to pharmacological treatments, neonatal pharmacology is different from …

Welcome to the 29th edition of Nelson's Pediatric Antimicrobial Therapy, the third edition
written during the COVID-19 pandemic, which continues to significantly affect our lives and …

Rational drug use in special populations is a clinical problem that doctors and pharma-cists
must consider seriously. Neonates are the most physiologically immature and vulnerable to …

Aims Therapeutic drug monitoring (TDM) of gentamicin in neonates is recommended for
safe and effective dosing and is currently performed by plasma sampling, which is an …

Sepsis in neonates and infants remains a major cause of death despite a decline in child
mortality and morbidity over the last decades. A key factor in further reducing poor clinical …

Clinical studies in preterm neonates are rarely performed due to ethical concerns and
difficulties associated with trials and recruitment. Consequently, dose selection in this …

Rational medicine use in neonates implies the prescription and administration of age-
appropriate drug formulations, selecting the most efficacious and safe dose, all based on …

Developmental changes that occur throughout childhood have long been known to impact
drug disposition. However, pharmacokinetic studies in the paediatric population have …

Abstract Background The Dutch Pediatric Formulary (DPF) increasingly bases its guidelines
on model-based dosing simulations from pharmacokinetic studies. This resulted in …