[HTML][HTML] The biological applications of DNA nanomaterials: current challenges and future directions
W Ma, Y Zhan, Y Zhang, C Mao, X Xie… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …
biological applications as driven by DNA nanotechnology in the past decades, including …
[HTML][HTML] Hydrogels as drug delivery systems: A review of current characterization and evaluation techniques
Owing to their tunable properties, controllable degradation, and ability to protect labile
drugs, hydrogels are increasingly investigated as local drug delivery systems. However, a …
drugs, hydrogels are increasingly investigated as local drug delivery systems. However, a …
[HTML][HTML] Integration of substrate-and flow-derived stresses in endothelial cell mechanobiology
CA Dessalles, C Leclech, A Castagnino… - Communications …, 2021 - nature.com
Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …
that regulate their structure and function in health and disease. Here, we review EC …
A vascularized model of the human liver mimics regenerative responses
Liver regeneration is a well-orchestrated process that is typically studied in animal models.
Although previous animal studies have offered many insights into liver regeneration, human …
Although previous animal studies have offered many insights into liver regeneration, human …
[HTML][HTML] The Importance of Mechanical Forces for in vitro Endothelial Cell Biology
Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …
their luminal and abluminal extracellular environments. These interactions confer physical …
Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applications
MC Decarli, R Amaral, DP Dos Santos, LB Tofani… - …, 2021 - iopscience.iop.org
Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …
Microfluidic trends in drug screening and drug delivery
The low probability of a drug candidate's clinical success, the time consumed and the high
cost of bringing a drug from concept to market emphasizes the need for new approaches to …
cost of bringing a drug from concept to market emphasizes the need for new approaches to …
[HTML][HTML] Development of a perfusable, hierarchical microvasculature-on-a-chip model
Several methods have been developed for generating 3D, in vitro, organ-on-chip models of
human vasculature to study vascular function, transport, and tissue engineering. However …
human vasculature to study vascular function, transport, and tissue engineering. However …
Hepatocellular carcinoma organoid co-cultures mimic angiocrine crosstalk to generate inflammatory tumor microenvironment
Hepatocellular carcinoma (HCC) is the sixth most common cancer and the second leading
cause of cancer worldwide. Despite approvals of several therapeutics to treat advanced …
cause of cancer worldwide. Despite approvals of several therapeutics to treat advanced …
Microporogen‐Structured Collagen Matrices for Embedded Bioprinting of Tumor Models for Immuno‐Oncology
Embedded bioprinting enables the rapid design and fabrication of complex tissues that
recapitulate in vivo microenvironments. However, few biological matrices enable good print …
recapitulate in vivo microenvironments. However, few biological matrices enable good print …