Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Tryptophan metabolism in depression: a narrative review with a focus on serotonin and kynurenine pathways

AS Correia, N Vale - International journal of molecular sciences, 2022 - mdpi.com
Depression is a common and serious disorder, characterized by symptoms like anhedonia,
lack of energy, sad mood, low appetite, and sleep disturbances. This disease is very …

[HTML][HTML] Blockade of GCH1/BH4 axis activates ferritinophagy to mitigate the resistance of colorectal cancer to erastin-induced ferroptosis

Q Hu, W Wei, D Wu, F Huang, M Li, W Li… - Frontiers in cell and …, 2022 - frontiersin.org
Ferroptosis, a type of cell death triggered by excessive accumulation of iron-dependent lipid
peroxidation, possesses an excellent potential in cancer treatment. However, many …

Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice

AM Rosenberg, M Saggar, AS Monzel, J Devine… - Nature …, 2023 - nature.com
The brain and behavior are under energetic constraints, limited by mitochondrial energy
transformation capacity. However, the mitochondria-behavior relationship has not been …

Noncoding RNAs link metabolic reprogramming to immune microenvironment in cancers

Y Zhang, Q Mao, Q Xia, J Cheng, Z Huang, Y Li… - Journal of hematology & …, 2021 - Springer
Altered metabolic patterns in tumor cells not only meet their own growth requirements but
also shape an immunosuppressive microenvironment through multiple mechanisms …

[HTML][HTML] Ferroptosis: a critical moderator in the life cycle of immune cells

P Wang, YQ Lu - Frontiers in immunology, 2022 - frontiersin.org
Ferroptosis is a form of programmed cell death that was only recognized in 2012. Until
recently, numerous researchers have turned their attention to the mechanism and function of …

Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential

X Ding, L Gao, Z Han, S Eleuteri, W Shi, Y Shen… - Ageing Research …, 2023 - Elsevier
Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …

Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors

C Scarpellini, G Klejborowska, C Lanthier… - Trends in …, 2023 - cell.com
Ferroptosis is an iron-catalysed form of regulated cell death, which is critically dependent on
phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic …

Nitric oxide/nitric oxide synthase system in the pathogenesis of neurodegenerative disorders—an overview

OM Iova, GE Marin, I Lazar, I Stanescu, G Dogaru… - Antioxidants, 2023 - mdpi.com
Nitric oxide, a ubiquitous molecule found throughout the natural world, is a key molecule
implicated in many central and benefic molecular pathways and has a well-established role …

[PDF][PDF] Treatment of 95 post-Covid patients with SSRIs

CP Rus, BEK de Vries, IEJ de Vries, I Nutma… - Scientific reports, 2023 - nature.com
Abstract After Covid-19 infection, 12.5% develops post-Covid-syndrome (PCS). Symptoms
indicate numerous affected organ systems. After a year, chronic fatigue, dysautonomia and …