Prokaryotic secretion relies on proteins that are widely conserved, including NTPases and
secretins, and on proteins that are system specific. The Tad secretion system in …

Secretin is a large outer-membrane channel found in secretion systems of Gram-negative
bacteria, facilitating the last step for transfer of proteins into the extracellular environment. In …

Current tomographic methods of cancer detection have limited sensitivity and are unable to
detect malignant masses smaller than half a centimeter in diameter. Mortality from tumor …

Secretion of cholera toxin and other virulence factors from Vibrio cholerae is mediated by the
type II secretion (T2S) apparatus, a multiprotein complex composed of both inner and outer …

Pseudomonas aeruginosa is an opportunistic pathogen implicated in a myriad of infections
and a leading pathogen responsible for mortality in patients with cystic fibrosis (CF) …

Disulfide bond formation is required for the folding of many bacterial virulence factors.
However, whereas the Escherichia coli disulfide bond-forming system is well characterized …

Type IV fimbriae are essential virulence factors of Dichelobacter nodosus, the principal
causative agent of ovine foot rot. The fimA fimbrial subunit gene is required for virulence, but …

Ovine footrot is a contagious and debilitating disease that is of major economic significance
to the sheep meat and wool industries. The causative bacterium is the gram negative …

The objective of this study was to develop an understanding of the molecular mechanisms
by which type IV fimbrial biogenesis, natural transformation, and protease secretion are …

Tertiary and quaternary structures of extracytoplasmic proteins containing more than one
cysteine residue often require introduction of disulfide bonds. This process takes place in an …