Recognition of tumors by the innate immune system and natural killer cells

A Marcus, BG Gowen, TW Thompson, A Iannello… - Advances in …, 2014 - Elsevier
In recent years, roles of the immune system in immune surveillance of cancer have been
explored using a variety of approaches. The roles of the adaptive immune system have been …

Self-tolerance of natural killer cells

DH Raulet, RE Vance - Nature Reviews Immunology, 2006 - nature.com
Natural killer (NK) cells, similar to other lymphocytes, acquire tolerance to self. This means
that NK cells have the potential to attack normal self cells but that there are mechanisms to …

Human natural killer cell development

AG Freud, MA Caligiuri - Immunological reviews, 2006 - Wiley Online Library
Our understanding of human natural killer (NK) cell development lags far behind that of
human B‐or T‐cell development. Much of our recent knowledge of this incomplete picture …

[HTML][HTML] The common marmoset genome provides insight into primate biology and evolution

TMG Sequencing, Analysis Consortium - Nature genetics, 2014 - ncbi.nlm.nih.gov
A first analysis of the genome sequence of the common marmoset (Callithrix jacchus),
assembled using traditional Sanger methods and Ensembl annotation, has permitted …

Advances in understanding the roles of CD244 (SLAMF4) in immune regulation and associated diseases

L Sun, X Gang, Z Li, X Zhao, T Zhou, S Zhang… - Frontiers in …, 2021 - frontiersin.org
Proteins in the signaling lymphocytic activating molecule (SLAM) family play crucial roles in
regulating the immune system. CD244 (SLAMF4) is a protein in this family, and is also a …

Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses

S Nedvetzki, S Sowinski, RA Eagle, J Harris, F Vély… - Blood, 2007 - ashpublications.org
Natural killer (NK) cells directly lyse tumor or viral-infected cells but also an important role for
NK cell cytotoxicity in regulating the extent of immune responses is emerging. Here, we …

Immune regulation by SLAM family receptors and SAP-related adaptors

A Veillette - Nature Reviews Immunology, 2006 - nature.com
The signalling lymphocytic activation molecule (SLAM) family of receptors is expressed by a
wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors …

A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature

S Cooley, F Xiao, M Pitt, M Gleason… - Blood, The Journal …, 2007 - ashpublications.org
How receptor acquisition correlates with the functional maturation of natural killer (NK) cells
is poorly understood. We used quantitative real-time polymerase chain reaction (PCR) …

SLAM-family receptors: immune regulators with or without SAP-family adaptors

A Veillette - Cold Spring Harbor perspectives in biology, 2010 - cshperspectives.cshlp.org
The signaling lymphocytic activation molecule (SLAM) family of receptors and the SLAM-
associated protein (SAP) family of intracellular adaptors are expressed in immune cells. By …

Regulation of NK cell responsiveness to achieve self‐tolerance and maximal responses to diseased target cells

NT Joncker, DH Raulet - Immunological reviews, 2008 - Wiley Online Library
Inhibitory receptors specific for major histocompatibility complex (MHC) class I molecules
govern the capacity of natural killer (NK) cells to attack class I‐deficient cells ('missing‐self …