Activation and regulation of purinergic P2X receptor channels
Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …
P2X receptors
RA North - … Transactions of the Royal Society B …, 2016 - royalsocietypublishing.org
Extracellular adenosine 5′-triphosphate (ATP) activates cell surface P2X and P2Y
receptors. P2X receptors are membrane ion channels preferably permeable to sodium …
receptors. P2X receptors are membrane ion channels preferably permeable to sodium …
Molecular mechanism of ATP binding and ion channel activation in P2X receptors
P2X receptors are trimeric ATP-activated ion channels permeable to Na+, K+ and Ca2+. The
seven P2X receptor subtypes are implicated in physiological processes that include …
seven P2X receptor subtypes are implicated in physiological processes that include …
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
AI Sobolevsky, MP Rosconi, E Gouaux - Nature, 2009 - nature.com
Ionotropic glutamate receptors mediate most excitatory neurotransmission in the central
nervous system and function by opening a transmembrane ion channel upon binding of …
nervous system and function by opening a transmembrane ion channel upon binding of …
Crystal structure of the ATP-gated P2X4 ion channel in the closed state
P2X receptors are cation-selective ion channels gated by extracellular ATP, and are
implicated in diverse physiological processes, from synaptic transmission to inflammation to …
implicated in diverse physiological processes, from synaptic transmission to inflammation to …
Signaling at purinergic P2X receptors
A Surprenant, RA North - Annual review of physiology, 2009 - annualreviews.org
P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X
receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of …
receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of …
Molecular and functional properties of P2X receptors—recent progress and persisting challenges
K Kaczmarek-Hájek, É Lörinczi, R Hausmann… - Purinergic …, 2012 - Springer
Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …
A functional P2X7 splice variant with an alternative transmembrane domain 1 escapes gene inactivation in P2X7 knock-out mice
A Nicke, YH Kuan, M Masin, J Rettinger… - Journal of Biological …, 2009 - ASBMB
The ATP-activated P2X7 receptor channel is involved in immune function and inflammatory
pain and represents an important drug target. Here we describe a new P2X7 splice variant …
pain and represents an important drug target. Here we describe a new P2X7 splice variant …
Ligand-gated ion channels: new insights into neurological disorders and ligand recognition
1. INTRODUCTION Ligand-gated ion channels (LGICs) mediate intercellular communication
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …
New structure enlivens interest in P2X receptors
P2X receptors are ATP-gated membrane ion channels with multifarious roles, including
afferent sensation, autocrine feedback loops, and inflammation. Their molecular operation …
afferent sensation, autocrine feedback loops, and inflammation. Their molecular operation …