For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Basement membranes are layers of extracellular matrix which anchor the epithelium or
endothelium to connective tissues in most organs. Descemet's membrane—which is the …

Highly effective cystic fibrosis (CF) transmembrane conductance regulator (CFTR) modulator
therapies (HEMT), including elexacaftor-tezacaftor-ivacaftor, correct the underlying …

Cornea, a dome-shaped and transparent front part of the eye, affords 2/3rd refraction and
barrier functions. Globally, corneal diseases are the leading cause of vision impairment …

Mutations in effectors of the hedgehog signaling pathway are responsible for a wide variety
of ocular developmental anomalies. These range from massive malformations of the brain …

The circadian timing system optimizes health by temporally coordinating behavior and
physiology. During mammalian gestation, fetal circadian rhythms are synchronized by the …

Caffeine is the globally consumed psychoactive substance and the drug of choice for the
treatment of apnea of prematurity (AOP), but its therapeutic effects are highly variable among …

Congenital cone-rod synaptic disorder (CRSD), also known as incomplete congenital
stationary night blindness (iCSNB), is a non-progressive inherited retinal disease (IRD) …

The vertebrate retina develops from a specified group of precursor cells that adopt distinct
identities and generate lineages of either the neural retina, retinal pigmented epithelium, or …

Immunodeficient mice engrafted with human immune cells represent an innovative tool to
improve translatability of animal models for the study of human diseases …