The mouse skin has become the model of choice to study the regulation and function of AP-
1 subunits in many physiological and pathological processes in vivo and in vitro. Genetically …

Given the associations between chronic inflammation and epithelial cancer 1, 2 we studied
susceptibility to skin carcinogenesis 3, 4 in mice deficient for the pro-inflammatory cytokine …

The activity of chemical carcinogens is a complex balance between metabolic activation by
cytochrome P450 monooxygenases and detoxification by enzymes such as glutathione S …

Activator protein-1 (AP-1) is a transcription factor that consists of either a Jun-Jun
homodimer or a Jun-Fos heterodimer. Transactivation of AP-1 is required for tumor promoter …

Anthocyanins are the chemical components that give the intense color to many fruits and
vegetables, such as blueberries, red cabbages and purple sweet potatoes. Extensive …

The cutaneous human papillomavirus (HPV) 8 is clearly involved in skin cancer
development in epidermodysplasia verruciformis patients and its early genes E2, E6, and E7 …

Reproducible multi-stage progression to invasive squamous carcinoma of the epidermis has
been achieved in transgenic mice expressing the HPV16 early-region genes, including the …

Viability-promoting genes such as BCL2 play an important role in human cancer but do not
directly cause aggressive tumors. BCL2 transgenic mice develop lymphoma at low …

KLF4/GKLF normally functions in differentiating epithelial cells, but also acts as a
transforming oncogene in vitro. To examine the role of this zinc finger protein in skin, we …

Generation of reactive oxygen species (ROS) has been implicated in the development of
cancer. Groundwork establishing mitochondria as a critical source of ROS generation and …