[HTML][HTML] Chrysin: Perspectives on contemporary status and future possibilities as pro-health agent

M Stompor-Gorący, A Bajek-Bil, M Machaczka - Nutrients, 2021 - mdpi.com
Chrysin belongs to the group of natural polyphenols. It can be found, among others, in
honey, propolis and fruits and has a wide range of biological activities, including the …

A comprehensive and current review on the role of flavonoids in lung cancer–Experimental and theoretical approaches

Ş Berk, S Kaya, EK Akkol, H Bardakçı - Phytomedicine, 2022 - Elsevier
Background It is well-known that flavonoids, which can be easily obtained from many fruits
and vegetables are widely preferred in the treatment of some important diseases. Some …

Halogenated baicalein as a promising antiviral agent toward SARS-CoV-2 main protease

K Hengphasatporn, P Wilasluck… - Journal of Chemical …, 2022 - ACS Publications
The coronavirus disease pandemic is a constant reminder that global citizens are in
imminent danger of exposure to emerging infectious diseases. Therefore, developing a …

Designing Potent α-Glucosidase Inhibitors: A Synthesis and QSAR Modeling Approach for Biscoumarin Derivatives

THT Phan, K Hengphasatporn, Y Shigeta, W Xie… - ACS …, 2023 - ACS Publications
Nineteen biscoumarins were synthesized, well-characterized, and evaluated against α-
glucosidases in vitro. Of these, six compounds (10, 12, 16, and 17–19) were newly …

Modification of flavonoids: Methods and influences on biological activities

C Li, T Dai, J Chen, M Chen, R Liang… - Critical Reviews in …, 2023 - Taylor & Francis
Flavonoids are important active ingredients in plant-based food, which have many beneficial
effects on health. But the low solubility, poor oral bioavailability, and inferior stability of many …

Discussion on the structural modification and anti-tumor activity of flavonoids

ZG Zhou, DD Li, Y Chen, X Chen… - Current Topics in …, 2022 - ingentaconnect.com
Flavonoids are secondary metabolites of plants. In general# 140; most flavonoids are
combined with glucosides and have extremely complex molecular structures. In nature …

[HTML][HTML] Structural investigation of interactions between halogenated flavonoids and the lipid membrane along with their role as cytotoxic agents

A Dudek, N Szulc, A Pawlak, P Strugała-Danak… - Scientific Reports, 2024 - nature.com
This study focuses on understanding the structural and molecular changes in lipid
membranes under the influence of six halogenated flavonoid derivatives differing in the …

[HTML][HTML] Designing multi-target-directed flavonoids: a strategic approach to Alzheimer's disease

S Park, M Kim, Y Lin, M Hong, G Nam… - Chemical …, 2023 - pubs.rsc.org
The underlying causes of Alzheimer's disease (AD) remain a mystery, with multiple
pathological components, including oxidative stress, acetylcholinesterase, amyloid-β, and …

Improvement of the solubility and anticancer activity of 6, 8-dibromochrysin by encapsulation into β-cyclodextrin and its derivatives

K Kerdpol, A Oo, P Mahalapbutr, D Todsaporn… - Journal of the Taiwan …, 2023 - Elsevier
Abstract Background 6, 8-dibromochrysin (BrCN), a halogenated chrysin, possesses a
profound bioactivity against dengue and Zika viruses and various types of cancer. However …

[HTML][HTML] A promiscuous halogenase for the derivatization of flavonoids

D Kolling, M Stierhof, C Lasch, M Myronovskyi… - Molecules, 2021 - mdpi.com
Halogenation often improves the bioactive properties of natural products and is used in
pharmaceutical research for the generation of new potential drug leads. High regio-and …