Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Inhibitors of MAO-A and MAO-B are in clinical use for the treatment of psychiatric and
neurological disorders respectively. Elucidation of the molecular structure of the active sites …

In the mammalian central nervous system, reactive oxygen species (ROS) generation is
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …

Ferroptosis is a novel type of cell death characterized by iron-dependent lipid peroxidation
that involves a variety of biological processes, such as iron metabolism, lipid metabolism …

The homeostasis of iron is vital to human health, and iron dyshomeostasis can lead to
various disorders. Iron homeostasis is maintained by iron regulatory proteins (IRP1 and …

Dysfunction of iron metabolism, which includes its uptake, storage, and release, plays a key
role in neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer's …

Parkinson's disease (PD) is the second most common neurodegenerative disorder
characterized by progressive loss of dopaminergic neurons in the substantia nigra. The …

Iron chelation has been introduced as a new therapeutic concept for the treatment of
neurodegenerative diseases with features of iron overload. At difference with iron chelators …

In early 1920s, tyramine oxidase was discovered that metabolized tyramine and in 1933
Blaschko demonstrated that this enzyme also metabolized adrenaline, noradrenaline and …

Currently, we still lack effective measures to modify disease progression in
neurodegenerative diseases. Iron-containing proteins play an essential role in many …