The administration of MPTP selectively targets the dopaminergic system resulting in
Parkinsonism-like symptoms and is commonly used as a mice model of Parkinson's disease …

Retinitis pigmentosa (RP) is a group of inherited diseases in which mutations result in the
initial loss of night vision, followed by complete blindness. There is currently no effective …

Abstract Background Neurodegenerative disorders (NDDs) are associated with increased
activities of brain acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and …

Most alkaloids are produced by plants as a defense mechanism against herbivores. Since
alkaloids are known to possess pharmacological effects, this study sought to investigate the …

Neurodegenerative disorders (NDDs) are associated with increased activities of the brain
acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and β-secretase enzyme …

Neurodegenerative diseases such as Parkinson's disease (PD) have complex pathogenetic
mechanisms. Genetic, age, and environmental factors are all related to PD. Due to the …

Accumulation of evidence has demonstrated high levels of iron in the central nervous
system of both sporadic and familial amyotrophic lateral sclerosis (ALS) patients and in ALS …

Polysubstituted piperazine derivatives, designed as new iron chelators, were synthesized
and fully characterized by nuclear magnetic resonance and mass spectroscopy. Their …

Iron has been proposed to be responsible for neuronal loss in several diseases of the
central nervous system, including Alzheimer's disease (AD), Parkinson's disease (PD) …

Neurodegenerative diseases share a common pathogenetic mechanism involving
aggregation and deposition of misfolded proteins, oxidative stress, metal dyshomeostasis …