Multitarget anti-Alzheimer hybrid compounds: do they work in vivo?
D Muñoz-Torrero - Design of Hybrid Molecules for Drug Development, 2017 - Elsevier
The difficult-to-refuse argument that simultaneous modulation of several key biological
targets of a complex pathological network can lead to more efficient therapies than those …
targets of a complex pathological network can lead to more efficient therapies than those …
3 种不同脑区定点注射6-OHDA 单侧损伤大鼠帕金森病模型的比较研究
李进， 孙杰， 赵楠， 吴钧， 刘俊， 马钢 - 河北医科大学学报, 2016 - cqvip.com
目的从神经行为学, 组织病理和生化方面对3 种不同脑区单侧定点注射6-羟基多巴胺(6-
hydroxydopamine, 6-OHDA) 损伤大鼠帕金森病(Parkinson disease, PD) 模型进行比较研究 …
hydroxydopamine, 6-OHDA) 损伤大鼠帕金森病(Parkinson disease, PD) 模型进行比较研究 …
Monoamine oxidase-B inhibitor protects degenerating spinal neurons, enhances nerve regeneration and functional recovery in sciatic nerve crush injury model
Abstract Monoamine oxidase-B (MAOB), a flavin adenine dinucleotide (FAD), is an enzyme
which catalyzes the oxidation of amines. MAOB is proposed to play a major role in the …
which catalyzes the oxidation of amines. MAOB is proposed to play a major role in the …
Activity determination of human monoamine oxidase B (Mao B) by selective capturing and amperometric hydrogen peroxide detection
S Höfs, T Greiner, G Göbel, A Talke, F Lisdat - Sensors and Actuators B …, 2021 - Elsevier
The enzyme monoamine oxidase B (Mao B), which is involved in dopamine metabolism, is
an important drug target in Parkinson's disease (PD). The medical treatment with several …
an important drug target in Parkinson's disease (PD). The medical treatment with several …
Multiple ligands in neurodegenerative diseases
J Lalut, C Rochais… - Drug selectivity: an …, 2017 - Wiley Online Library
The application of multitarget‐directed ligand (MTDL) concept to complex etiology of
neurodegenerative diseases has been completely described by Cavalli. This chapter …
neurodegenerative diseases has been completely described by Cavalli. This chapter …
[HTML][HTML] 铁死亡调控机制及其在帕金森病中的研究进展
赵喆， 鲍秀琦， 张丹 - 药学学报, 2019 - html.rhhz.net
铁死亡是一种新型的细胞程序性死亡方式, 其形态, 生化特征及作用机制均不同于凋亡, 自噬,
坏死, 焦亡等已知的细胞死亡形式. 铁死亡的调控机制主要涉及铁代谢, 氨基酸代谢及脂质代谢 …
坏死, 焦亡等已知的细胞死亡形式. 铁死亡的调控机制主要涉及铁代谢, 氨基酸代谢及脂质代谢 …
Sex-dependent monoamine oxidase isoforms expression patterns during human brain ageing
C Sanfilippo, P Castrogiovanni, R Imbesi… - Mechanisms of Ageing …, 2021 - Elsevier
Human behavior is influenced by both genetic and environmental factors. Monoamine
oxidase A (MAOA) is among the most investigated genetic determinants of violent behaviors …
oxidase A (MAOA) is among the most investigated genetic determinants of violent behaviors …
M30 antagonizes indoleamine 2, 3-dioxygenase activation and neurodegeneration induced by corticosterone in the hippocampus
CS Lam, GL Tipoe, JKC Wong, MBH Youdim, ML Fung - Plos one, 2016 - journals.plos.org
Monoamine oxidases (MAO), downstream targets of glucocorticoid, maintain the turnover
and homeostasis of monoamine neurotransmitters; yet, its pathophysiological role in …
and homeostasis of monoamine neurotransmitters; yet, its pathophysiological role in …
Monoamine oxidase inhibitor (MAO-I)-mediated neuroprotection for treating Parkinson's disease
T Nagatsu, A Nakashima - NeuroPsychopharmacotherapy, 2020 - Springer
Monoamine oxidases (MAO)-A and MAO-B catalyze the oxidative deamination of
monoamine neurotransmitters, such as dopamine (DA), noradrenaline, and serotonin, in the …
monoamine neurotransmitters, such as dopamine (DA), noradrenaline, and serotonin, in the …
Применение аппарата теории игр для анализа проблем микроэкономики
АА Дорошенко - Новая наука: проблемы и перспективы, 2017 - elibrary.ru
Теория игр-математический метод изучения оптимальных стратегий в играх. Под игрой
понимается процесс, в котором участвуют две и более стороны, ведущих борьбу за …
понимается процесс, в котором участвуют две и более стороны, ведущих борьбу за …