[HTML][HTML] A meta-analysis of brain DNA methylation across sex, age, and Alzheimer's disease points for accelerated epigenetic aging in neurodegeneration
C Pellegrini, C Pirazzini, C Sala, L Sambati… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …
(DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect …
Ten years of EWAS
S Wei, J Tao, J Xu, X Chen, Z Wang, N Zhang… - Advanced …, 2021 - Wiley Online Library
Epigenome‐wide association study (EWAS) has been applied to analyze DNA methylation
variation in complex diseases for a decade, and epigenome as a research target has …
variation in complex diseases for a decade, and epigenome as a research target has …
[HTML][HTML] DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types
G Shireby, EL Dempster, S Policicchio… - Nature …, 2022 - nature.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the
progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex …
progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex …
[HTML][HTML] Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders
Background People with neurodegenerative disorders show diverse clinical syndromes,
genetic heterogeneity, and distinct brain pathological changes, but studies report overlap …
genetic heterogeneity, and distinct brain pathological changes, but studies report overlap …
[HTML][HTML] A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex
Epigenome-wide association studies of Alzheimer's disease have highlighted
neuropathology-associated DNA methylation differences, although existing studies have …
neuropathology-associated DNA methylation differences, although existing studies have …
[HTML][HTML] Association of peripheral blood DNA methylation level with Alzheimer's disease progression
Background Identifying biomarkers associated with Alzheimer's disease (AD) progression
may enable patient enrichment and improve clinical trial designs. Epigenome-wide …
may enable patient enrichment and improve clinical trial designs. Epigenome-wide …
[HTML][HTML] Epigenome-wide association study of Alzheimer's disease replicates 22 differentially methylated positions and 30 differentially methylated regions
QS Li, Y Sun, T Wang - Clinical epigenetics, 2020 - Springer
Background Growing evidence shows that epigenetic modifications play a role in
Alzheimer's disease (AD). We performed an epigenome-wide association study (EWAS) to …
Alzheimer's disease (AD). We performed an epigenome-wide association study (EWAS) to …
[HTML][HTML] Recent evidence in epigenomics and proteomics biomarkers for early and minimally invasive diagnosis of Alzheimer's and Parkinson's diseases
Background: Alzheimer's (AD) and Parkinson's diseases (PD) show deposits of improperly
folded modified proteins. Protein expression mechanisms are involved since the early …
folded modified proteins. Protein expression mechanisms are involved since the early …
[HTML][HTML] Identification of candidate DNA methylation biomarkers related to Alzheimer's disease risk by integrating genome and blood methylome data
Alzheimer disease (AD) is a common neurodegenerative disease with a late onset. It is
critical to identify novel blood-based DNA methylation biomarkers to better understand the …
critical to identify novel blood-based DNA methylation biomarkers to better understand the …
[HTML][HTML] Distinct CSF biomarker-associated DNA methylation in Alzheimer's disease and cognitively normal subjects
W Zhang, JI Young, L Gomez, MA Schmidt… - Alzheimer's research & …, 2023 - Springer
Background Growing evidence has demonstrated that DNA methylation (DNAm) plays an
important role in Alzheimer's disease (AD) and that DNAm differences can be detected in the …
important role in Alzheimer's disease (AD) and that DNAm differences can be detected in the …