[HTML][HTML] Integrated PPI-and WGCNA-retrieval of hub gene signatures shared between Barrett's esophagus and esophageal adenocarcinoma

AS Nangraj, G Selvaraj, S Kaliamurthi… - Frontiers in …, 2020 - frontiersin.org
Esophageal adenocarcinoma (EAC) is a deadly cancer with high mortality rate, especially in
economically advanced countries, while Barrett's esophagus (BE) is reported to be a …

Overview of methods for characterization and visualization of a protein–protein interaction network in a multi-omics integration context

V Robin, A Bodein, MP Scott-Boyer… - Frontiers in Molecular …, 2022 - frontiersin.org
At the heart of the cellular machinery through the regulation of cellular functions, protein-
protein interactions (PPI) have a significant role. PPI can be analysed with network …

In-depth study to decipher mechanisms underlying Arabidopsis thaliana tolerance to metal (loid) soil contamination in association with biochar and/or bacteria

M Simiele, G Sferra, M Lebrun, G Renzone… - … and experimental botany, 2021 - Elsevier
Metal (loid) s are toxic to animal life, human health and plants; therefore, their removal from
polluted areas is imperative in order to minimize their impact on the ecosystems. The use of …

Shexiang Tongxin Dropping Pill Protects Against Chronic Heart Failure in Mice via Inhibiting the ERK/MAPK and TGF-β Signaling Pathways

S Zhang, H Liu, Q Fang, H He, X Lu, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Background: Chronic heart failure (CHF) is a major public health problem with high mortality
and morbidity worldwide. Shexiang Tongxin Dropping Pill (STDP) is a widely used …

Bioinformatics Identification of Regulatory Genes and Mechanism Related to Hypoxia-Induced PD-L1 Inhibitor Resistance in Hepatocellular Carcinoma

M Huang, S Yang, WCS Tai, L Zhang, Y Zhou… - International Journal of …, 2023 - mdpi.com
The combination of a PD-L1 inhibitor and an anti-angiogenic agent has become the new
reference standard in the first-line treatment of non-excisable hepatocellular carcinoma …

[HTML][HTML] Identifying potential drug targets and candidate drugs for COVID-19: biological networks and structural modeling approaches

G Selvaraj, S Kaliamurthi, GH Peslherbe… - F1000Research, 2021 - ncbi.nlm.nih.gov
Background: Coronavirus (CoV) is an emerging human pathogen causing severe acute
respiratory syndrome (SARS) around the world. Earlier identification of biomarkers for SARS …

[HTML][HTML] Coexpression network analysis of human candida infection reveals key modules and hub genes responsible for host-pathogen interactions

S Naik, A Mohammed - Frontiers in Genetics, 2022 - frontiersin.org
Invasive fungal infections are a significant reason for morbidity and mortality among organ
transplant recipients. Therefore, it is critical to investigate the host and candida niches to …

Circulating mir-1246 targeting UBE2C, TNNI3, TRAIP, UCHL1 genes and key pathways as a potential biomarker for lung adenocarcinoma: integrated biological …

S Huang, YK Wei, S Kaliamurthi, Y Cao… - Journal of personalized …, 2020 - mdpi.com
Analysis of circulating miRNAs (cmiRNAs) before surgical operation (BSO) and after the
surgical operation (ASO) has been informative for lung adenocarcinoma (LUAD) diagnosis …

An effective prognostic model for assessing prognosis of non-small cell lung cancer with brain metastases

R Wang, X Zhang, C He, W Guo - Frontiers in Genetics, 2023 - frontiersin.org
Background: Brain metastasis, with an incidence of more than 30%, is a common
complication of non-small cell lung cancer (NSCLC). Therefore, there is an urgent need for …

Danshen-Chuanxiongqin Injection attenuates cerebral ischemic stroke by inhibiting neuroinflammation via the TLR2/TLR4-MyD88-NF-κB Pathway in tMCAO mice

XU Xiao-Jing, L Jin-Bo, JIN Kai-Yu, C Li-Bing… - Chinese Journal of …, 2021 - Elsevier
Abstract Danshen-Chuanxiongqin Injection (DCI) is a commonly used traditional Chinese
medicine for the treatment of cerebral ischemic stroke in China. However, its underlying …