[HTML][HTML] Future medicine: from molecular pathways to the collective intelligence of the body
The remarkable anatomical homeostasis exhibited by complex living organisms suggests
that they are inherently reprogrammable information-processing systems that offer …
that they are inherently reprogrammable information-processing systems that offer …
Collective intelligence: A unifying concept for integrating biology across scales and substrates
P McMillen, M Levin - Communications Biology, 2024 - nature.com
A defining feature of biology is the use of a multiscale architecture, ranging from molecular
networks to cells, tissues, organs, whole bodies, and swarms. Crucially however, biology is …
networks to cells, tissues, organs, whole bodies, and swarms. Crucially however, biology is …
The multiple realizability of sentience in living systems and beyond
Brains implement some of the most complex functions of living systems including
intelligence, decision-making, learning, and sentience, which is the capacity for subjective …
intelligence, decision-making, learning, and sentience, which is the capacity for subjective …
Sentient cells as basic units of tissues, organs and organismal physiology
Cells evolved some 4 billion years ago, and since then the integrity of the structural and
functional continuity of cellular life has been maintained via highly conserved and ancient …
functional continuity of cellular life has been maintained via highly conserved and ancient …
The mega‐evolution of life with its three memory systems depends on sender–receiver communication and problem‐solving. A narrative review
A De Loof - The Journal of Physiology, 2023 - Wiley Online Library
It should be the ultimate goal of any theory of evolution to delineate the contours of an
integrative system to answer the question: How does life (in all its complexity) evolve (which …
integrative system to answer the question: How does life (in all its complexity) evolve (which …
Machine Learning for Hypothesis Generation in Biology and Medicine: Exploring the latent space of neuroscience and developmental bioelectricity
T O'Brien, J Stremmel, L Pio-Lopez, P McMillen… - Digital …, 2024 - pubs.rsc.org
Artificial intelligence is a powerful tool that could be deployed to accelerate the scientific
enterprise. Here we address a major unmet need: use of existing scientific literature to …
enterprise. Here we address a major unmet need: use of existing scientific literature to …
Aging as a loss of morphostatic information: a developmental bioelectricity perspective
L Pio-Lopez, M Levin - Ageing Research Reviews, 2024 - Elsevier
Maintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to
cancer and an accumulation of molecular and cellular disorders. Perhaps, the most …
cancer and an accumulation of molecular and cellular disorders. Perhaps, the most …
Array-wide Uniform PEDOT: PSS Electroplating from Potentiostatic Deposition
Abstract Electroplating of poly (3, 4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:
PSS) is important in many neuroelectronic applications but is challenging to achieve …
PSS) is important in many neuroelectronic applications but is challenging to achieve …
Unraveling the Enigma of Organismal Death: Insights, Implications, and Frontiers
Significant knowledge gaps exist regarding the responses of cells, tissues, and organs to
organismal death. Examining the survival mechanisms influenced by metabolism and …
organismal death. Examining the survival mechanisms influenced by metabolism and …
Correcting instructive electric potential patterns in multicellular systems: External actions and endogenous processes
Background Transmembrane electrical potential differences in cells modulate the spatio-
temporal distribution of signaling ions and molecules that are instructive for downstream …
temporal distribution of signaling ions and molecules that are instructive for downstream …