[HTML][HTML] Future medicine: from molecular pathways to the collective intelligence of the body

E Lagasse, M Levin - Trends in Molecular Medicine, 2023 - cell.com
The remarkable anatomical homeostasis exhibited by complex living organisms suggests
that they are inherently reprogrammable information-processing systems that offer …

Collective intelligence: A unifying concept for integrating biology across scales and substrates

P McMillen, M Levin - Communications Biology, 2024 - nature.com
A defining feature of biology is the use of a multiscale architecture, ranging from molecular
networks to cells, tissues, organs, whole bodies, and swarms. Crucially however, biology is …

The multiple realizability of sentience in living systems and beyond

N Rouleau, M Levin - Eneuro, 2023 - eneuro.org
Brains implement some of the most complex functions of living systems including
intelligence, decision-making, learning, and sentience, which is the capacity for subjective …

Sentient cells as basic units of tissues, organs and organismal physiology

F Baluška, WB Miller Jr, AS Reber - The Journal of Physiology, 2023 - Wiley Online Library
Cells evolved some 4 billion years ago, and since then the integrity of the structural and
functional continuity of cellular life has been maintained via highly conserved and ancient …

The mega‐evolution of life with its three memory systems depends on sender–receiver communication and problem‐solving. A narrative review

A De Loof - The Journal of Physiology, 2023 - Wiley Online Library
It should be the ultimate goal of any theory of evolution to delineate the contours of an
integrative system to answer the question: How does life (in all its complexity) evolve (which …

Machine Learning for Hypothesis Generation in Biology and Medicine: Exploring the latent space of neuroscience and developmental bioelectricity

T O'Brien, J Stremmel, L Pio-Lopez, P McMillen… - Digital …, 2024 - pubs.rsc.org
Artificial intelligence is a powerful tool that could be deployed to accelerate the scientific
enterprise. Here we address a major unmet need: use of existing scientific literature to …

Aging as a loss of morphostatic information: a developmental bioelectricity perspective

L Pio-Lopez, M Levin - Ageing Research Reviews, 2024 - Elsevier
Maintaining order at the tissue level is crucial throughout the lifespan, as failure can lead to
cancer and an accumulation of molecular and cellular disorders. Perhaps, the most …

Array-wide Uniform PEDOT: PSS Electroplating from Potentiostatic Deposition

Y Shin, J Ryu, T Bai, Y Qiang, Y Qi, G Li… - Biosensors and …, 2024 - Elsevier
Abstract Electroplating of poly (3, 4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:
PSS) is important in many neuroelectronic applications but is challenging to achieve …

Unraveling the Enigma of Organismal Death: Insights, Implications, and Frontiers

PA Noble, A Pozhitkov, K Singh, E Woods… - …, 2024 - journals.physiology.org
Significant knowledge gaps exist regarding the responses of cells, tissues, and organs to
organismal death. Examining the survival mechanisms influenced by metabolism and …

Correcting instructive electric potential patterns in multicellular systems: External actions and endogenous processes

J Cervera, M Levin, S Mafe - Biochimica et Biophysica Acta (BBA)-General …, 2023 - Elsevier
Background Transmembrane electrical potential differences in cells modulate the spatio-
temporal distribution of signaling ions and molecules that are instructive for downstream …