Overcoming colloidal nanoparticle aggregation in biological milieu for cancer therapeutic delivery: Perspectives of materials and particle design

SH Lim, TW Wong, WX Tay - Advances in Colloid and Interface Science, 2024 - Elsevier
Nanoparticles as cancer therapeutic carrier fail in clinical translation due to complex
biological environments in vivo consisting of electrolytes and proteins which render …

Targeting chronic myeloid leukemia stem/progenitor cells using venetoclax-loaded immunoliposome

M Houshmand, F Garello, R Stefania, V Gaidano… - Cancers, 2021 - mdpi.com
Simple Summary Chronic myeloid leukemia stem cells (CML LSCs) are a rare and
quiescent population that are resistant to tyrosine kinase inhibitors. CML LSCs have many …

Catalytic Neutralization of water pollutants mediated by dendritic polymers

M Arkas, I Anastopoulos, DA Giannakoudakis… - Nanomaterials, 2022 - mdpi.com
Radially polymerized dendritic compounds are nowadays an established polymer category
next to their linear, branched, and cross-linked counterparts. Their uncommon tree-like …

Nanoparticle delivery platforms for RNAi therapeutics targeting COVID-19 disease in the respiratory tract

Y Zhang, JG Almazi, HX Ong, MD Johansen… - International Journal of …, 2022 - mdpi.com
Since December 2019, a pandemic of COVID-19 disease, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread across the globe. At …

Dysregulated signalling pathways driving anticancer drug resistance

N Bou Antoun, AM Chioni - International Journal of Molecular Sciences, 2023 - mdpi.com
One of the leading causes of death worldwide, in both men and women, is cancer. Despite
the significant development in therapeutic strategies, the inevitable emergence of drug …

Bactericidal properties of rod-, peanut-, and star-shaped gold nanoparticles coated with ceragenin CSA-131 against multidrug-resistant bacterial strains

SJ Chmielewska, K Skłodowski, J Depciuch, P Deptuła… - Pharmaceutics, 2021 - mdpi.com
Background: The ever-growing number of infections caused by multidrug-resistant (MDR)
bacterial strains requires an increased effort to develop new antibiotics. Herein, we …

Effects of Gold Nanoparticles Functionalized with Bioactive Compounds from Cornus mas Fruit on Aorta Ultrastructural and Biochemical Changes in Rats on a …

R Moldovan, DR Mitrea, A Florea, IC Chiş, Ş Suciu… - Antioxidants, 2022 - mdpi.com
Cornus mas L. extract (CM) presents hypolipidemic, antioxidant and anti-inflammatory
activity. Gold nanoparticles (AuNPs) are considered potent delivery systems and may be …

Recent advances in ocular drug delivery systems and targeting VEGF receptors for management of ocular angiogenesis: A comprehensive review

S Narayana, MG Ahmed, BHJ Gowda… - Future Journal of …, 2021 - Springer
Background Angiogenic ocular diseases address the main source of vision impairment or
irreversible vision loss. The angiogenesis process depends on the balance between the pro …

The Hitchhiker's guide to human therapeutic nanoparticle development

TI Ramos, CA Villacis-Aguirre, KV López-Aguilar… - Pharmaceutics, 2022 - mdpi.com
Nanomedicine plays an essential role in developing new therapies through novel drug
delivery systems, diagnostic and imaging systems, vaccine development, antibacterial tools …

Melatonin loaded poly (lactic-co-glycolic acid)(PLGA) nanoparticles reduce inflammation, inhibit apoptosis and protect rat's liver from the hazardous effects of CCL4

A Farid, V Michael, G Safwat - Scientific Reports, 2023 - nature.com
Liver is an important organ that carries out major important functions including the
detoxification of harmful chemicals. Numerous studies have lately focused on the impact of …