A key goal in pharmaceutical development of dosage forms is a good understanding of the
in vitro and in vivo performance of the dosage forms. One of the challenges of …

The ability to predict drug disposition involves concurrent consideration of many chemical
and physiological variables and the effect of food on the rate and extent of availability adds …

The aims of the present study was to investigate if food components, as represented by a
multi-component nutritional drink for tube feeding, could affect tablet disintegration of …

The purpose of the present review was to systematically evaluate if aqueous solubility,
dose/solubility ratio, and partition coefficient (Log P) could be used as useful parameters to …

The purpose of the present work was developing an in vitro dissolution test to highlight the
possible molecular background causing ciprofloxacin (CPFX)–milk interaction. The in vitro …

Most correlations between in vitro and in vivo data (IVIVC) rely on linear relationships.
However, non-linear IVIVC can be also observed, justified and validated. The purpose of the …

PURPOSE: To validate Magnetic Moment Imaging (MMI) for the investigation of
gastrointestinal transit and disintegration of solid dosage forms and to correlate the MMI …

To study whether natural clinoptilolite could selectively capture Pb2+ ion in the aqueous
solution containing salt and glycine as well as nitrosamines, the natural zeolite was utilized …

Establishing an in vitro–in vivo correlation (IVIVC) is based on the ability to develop an in
vitro dissolution test that is predictive of the in vivo performance of the drug product. A …

In this study a novel type of in vitro–in vivo correlation (IVIVC) is proposed: The correlation of
the in vitro parent drug dissolution data with the in vivo pharmacokinetic data of drug's …