[HTML][HTML] The pivotal role of NF-kB in the pathogenesis and therapeutics of Alzheimer's disease

E Sun, A Motolani, L Campos, T Lu - International journal of molecular …, 2022 - mdpi.com
Alzheimer's Disease (AD) is the most common neurodegenerative disease worldwide, with a
high prevalence that is expected to double every 20 years. Besides the formation of Aβ …

[HTML][HTML] The effects of microglia-associated neuroinflammation on Alzheimer's disease

C Wang, S Zong, X Cui, X Wang, S Wu… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is defined as a severe chronic degenerative neurological disease
in human. The pathogenic mechanism of AD has been convincingly elucidated by the …

[HTML][HTML] Signal pathways in the treatment of Alzheimer's disease with traditional Chinese medicine

MR Ding, YJ Qu, B Hu, HM An - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Aim of the review This study aimed to reveal the classical signal pathways and important
potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD) …

A potential link between visceral obesity and risk of Alzheimer's disease

HM Al-Kuraishy, AI Al-Gareeb, AA Alsayegh… - Neurochemical …, 2023 - Springer
Alzheimer's disease (AD) is the most common type of dementia characterized by the
deposition of amyloid beta (Aβ) plaques and tau-neurofibrillary tangles in the brain. Visceral …

Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 post spinal …

M Xia, Y Zhang, H Wu, Q Zhang, Q Liu, G Li… - International …, 2022 - Elsevier
Background Spinal cord injury (SCI) is a ruinous neurological pathology that results in
locomotor and sensory impairment. Neuro-inflammation and secondary neuronal apoptosis …

[HTML][HTML] NF-κB Pathway and Its Inhibitors: A Promising Frontier in the Management of Alzheimer's Disease

BS Sivamaruthi, N Raghani, M Chorawala… - Biomedicines, 2023 - mdpi.com
The nuclear factor kappa B (NF-κB) pathway has emerged as a pivotal player in the
pathogenesis of various diseases, including neurodegenerative illnesses like Alzheimer's …

[HTML][HTML] Systematic review of the common pathophysiological mechanisms in COVID-19 and neurodegeneration: the role of bioactive compounds and natural …

K Choe, HY Park, M Ikram, HJ Lee, TJ Park, R Ullah… - Cells, 2022 - mdpi.com
The novel coronavirus (2019-nCoVCOVID-19) belongs to the Beta coronavirus family, which
contains MERS-CoV (Middle East respiratory syndrome coronavirus) and SARS-CoV …

[HTML][HTML] Review of the therapeutic potential of Forsythiae Fructus on the central nervous system: active ingredients and mechanisms of action

L Zhang, F Lang, J Feng, J Wang - Journal of Ethnopharmacology, 2023 - Elsevier
Abstract Ethnopharmacological relevance Traditional Chinese medicine has gained
significant attention in recent years owing to its multi-component, multi-target, and multi …

Aureonitol Analogues and Orsellinic Acid Esters Isolated from Chaetomium elatum and Their Antineuroinflammatory Activity

F Ju, QX Kuang, QZ Li, LJ Huang, WX Guo… - Journal of Natural …, 2021 - ACS Publications
Overexpression of various pro-inflammatory factors in microglial cells tends to induce
neurodegenerative diseases, for which there is no effective therapy available. Aureonitol (1) …

[HTML][HTML] Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice

CZ Yang, SH Wang, RH Zhang, JH Lin, YH Tian… - Cell Death …, 2023 - nature.com
As a small molecule flavonoid, astragalin (AST) has anti-inflammatory, anti-cancer, and anti-
oxidation effects. However, the impact and molecular mechanism of AST in Alzheimer's …