Satellite glial cells (SGCs) closely envelop cell bodies of neurons in sensory, sympathetic
and parasympathetic ganglia. This unique organization is not found elsewhere in the …

The management of orofacial pain to alleviate the quality of life of affected patients is
becoming increasingly challenging for scientific research and healthcare professionals …

The cornea is the most densely innervated and sensitive tissue in the body. The cornea is
exclusively innervated by C-and A-delta fibers, including mechano-nociceptors that are …

While pain chronicity in general has been defined as pain lasting for more than 3 months,
this definition is not useful in orofacial pain (OFP) and headache (HA). Instead, chronicity in …

Peripheral and central sensitizations of the trigeminal nervous system are the main
mechanisms to promote the development and maintenance of chronic orofacial pain …

Pain is a multidimensional experience comprising sensory-discriminative, affective-
motivational, and cognitive-evaluative dimensions. Clinical and research findings have …

Head and neck cancer (HNC) affects over 890,000 people annually worldwide and has a
mortality rate of 50%. Aside from poor survival, HNC pain impairs eating, drinking, and …

Neuropathic pain conditions including neuropathic orofacial pain (NOP) are difficult to treat.
Contemporary therapeutic agents for neuropathic pain are often ineffective in relieving pain …

Migraine is a complex and debilitating neurological disease that affects 15% of the
population worldwide. It is defined by the presence of recurrent severe attacks of disabling …

Excruciating trigeminal neuralgia (TN) management is very difficult and severely affects the
patient's quality of life. Earlier studies have shown that the trigeminal ganglion (TG) …